An Environmentally Benign System for Synthesis of β-Hydroxylketones： L-Histidine Asymmetrically Catalyzed Direct Aldol Reactions in Aqueous Micelle and Water-like Media  

作　　者：彭以元 彭淑君 丁秋平 王琦 程津培 

机构地区：[1]Department of Chemistry and State Key Laboratory of Elemento-organic Chemistry, Nankai University, Tianjin 300071, China [2]The Key Laboratory of Green Chemistry, Jiangxi Province and Department of Chemistry, Jiangxi Normal University, Nanchang, Jiangxi 330027, China

出　　处：《Chinese Journal of Chemistry》2007年第3期356-363,共8页中国化学（英文版）

基　　金：Project supported by the National Natural Science Foundation of China （Nos. 20342007, 20462003, 20452001 and 20421202）.

摘　　要：The first histidine catalyzed direct aldol reactions of ketones with nitrobenzaldehydes in water and in poly（ethylene glycol） （PEG） were reported. It reveals that histidine is a good aldol catalyst for synthesis of β-hydroxylketones in water and in PEG, giving good to excellent yields of the respective products. Better enantioand regioselectivity were achieved using low molecular weight PEG as the media. The results show that histidine and PEG-200 or -300 may constitute a promising environmentally benign system for asymmetric synthesis of β-hydroxylketones.The first histidine catalyzed direct aldol reactions of ketones with nitrobenzaldehydes in water and in poly（ethylene glycol） （PEG） were reported. It reveals that histidine is a good aldol catalyst for synthesis of β-hydroxylketones in water and in PEG, giving good to excellent yields of the respective products. Better enantioand regioselectivity were achieved using low molecular weight PEG as the media. The results show that histidine and PEG-200 or -300 may constitute a promising environmentally benign system for asymmetric synthesis of β-hydroxylketones.

关 键 词：HISTIDINE β-hydroxylketone asymmetric synthesis poly（ethylene glycol） 

分 类 号：O623.56[理学—有机化学]