Highly Efficient One-Pot Synthesis of 2-Arylmethyl N-Substituted Anilines via Yb（OTf）3 Catalyzed Three-Component Reaction  

作　　者：王利民 张亮 胡亮 田禾 

机构地区：[1]Laboratory for Advanced Materials & Institute of Fine Chemicals, East China University of Science and Technology, Shanghai 200237, China

出　　处：《Chinese Journal of Chemistry》2007年第3期370-374,共5页中国化学（英文版）

基　　金：Project supported by the National Natural Science Foundation of China （No. 20672035） and Key Laboratory of 0rganofluorine Chemistry, Shanghai Institute of 0rganic Chemistry, Chinese Academy of Sciences.

摘　　要：An efficient method has been developed for one-pot three-component coupling reactions of various aldehydes, 1-cyclohexen-2-one, and primary or secondary amines in the presence of a catalytic amount of Yb（OTf）3 under mild conditions to afford the corresponding 2-arylmethyl N-substituted anilines in good yields. In addition, the catalyst was easily recovered and could be reused for at least four cycles without any loss of activity.An efficient method has been developed for one-pot three-component coupling reactions of various aldehydes, 1-cyclohexen-2-one, and primary or secondary amines in the presence of a catalytic amount of Yb（OTf）3 under mild conditions to afford the corresponding 2-arylmethyl N-substituted anilines in good yields. In addition, the catalyst was easily recovered and could be reused for at least four cycles without any loss of activity.

关 键 词：Yb（OTf）3 2-arylmethyl N-substituted aniline ALDEHYDE 1-cyclohexen-2-one amine 

分 类 号：O625.632[理学—有机化学]