氯高铁血红素抗贫血疗效及追踪调查报告  

EFFECT OF HEMIN IN TREATING IRON DEFICIENCY ANEMIA AND FOLLEW-UP REPORT

作　　者：赵子庆[1] 吴斌[1] 黄妙辉[1] 游开绍[1] 黄自强[1] 

机构地区：[1]福建医学院附属第一医院儿科

出　　处：《中国小儿血液》1996年第2期56-58,共3页China Child Blood

摘　　要：本文报告用氯高铁血红素每天３００ｍｇ／ｋｇ、１５０ｍｇ／ｋｇ、５０ｍｇ／ｋｇ治疗失血性小鼠。治疗后Ｈｂ明显高于阴性对照组；大、中剂量组疗效优于葡萄糖酸亚铁组。对１２０例缺铁性贫血小儿予氯高铁血红素。服液治疗（１—２ｍｇ／ｋｇ·ｄ），治疗后Ｈｂ明显升高，ＦＥＰ明显下降；治愈率达８７．５％，总有效率１００％；治疗结束后３月，６月及１年追踪随访示有８７．５％、７５％、６０％小儿Ｈｂ≥１１０ｇ／Ｌ。提示：氯高铁血红素治疗缺铁性贫血具有良好的疗效。Abstract: To study the effect of hemin in treating iron deficiency anemia (IDA): Fifty mice with hemorrhagic anemia were randomly divided into 5(I-V) groups with different dosage. 1. of hemin (Ⅲ: 50mg· kg-1. d-1, Ⅳ: 150mg· kg-1. d-1, Ⅴ: 300mg. Kg-1· d-1): 2. ferrousgluconate (Ⅱ 300mg. kg-1ed· d-1)； 3. only water (Ⅰ). All orally for 7 days. One hundredand twenty children with IDA treated with hemin oral liquid (1-2mg·Kg-1. d-1) for 30days. Results showed: there are significant differences between the groups Ⅱ～Ⅴ and thegroup Ⅰ. The therapeutic effect of the groups Ⅳ、Ⅴ were surpassed that of the troup Ⅱ. After treatment, Hb and FEP of IDA children were 95. 3→123. 6g· L-1, 735. 2→426. 5ug·L-1. Cure rate was 87. 5%. The percentage of Hb≥110g· L-1 were 87. 5% at 3 month. 75%at 6 month, 60% at one year after freatment ending respectively. On conclusion: Hemincould have a good effect on treatment IDA.

关 键 词：氯高铁血红素 贫血 追踪调查 疗效 儿童 

分 类 号：R725.56[医药卫生—儿科] R977.8[医药卫生—临床医学]