急性肺损伤家兔肺表面活性物质磷脂含量、活性与肺功能关系的研究  

Relationship Between the Phospholipid Content and Activity of BALF and Lung Function in Acute Lung Injury of Rabbits

作　　者：秦环龙[1] 吴静怡[1] 

机构地区：[1]上海医科大学附属儿科医院

出　　处：《镇江医学院学报》1996年第3期232-233,共2页Journal of Zhenjiang Medical College

摘　　要：在家兔急性肺损伤模型中发现支气管肺胞灌洗液中磷脂含量较对照组显著下降（Ｐ＜０．０１），白蛋白指数显著上升Ｐ＜０．０１），肺系数明显升高（Ｐ＜０．０１）。表面活性物质活性测定发现表面张力显著升高（Ｐ＜０．０１）；稳定系数、回弹系数及滞后环面积均显著下降（Ｐ＜０．０５）。急性肺损伤组家兔肺组织电镜观察发现肺泡Ⅱ型上皮细胞排空。作者认为，肺泡表面活性物质质和量的异常在急性肺损伤的发病机制上具有重要作用。The phospholipid content in BALF markedly decreased (P<0.01) and Albumin Index increased P<0.01), and the lung index also increased (P<0.01) in the rabbits of acute lung injury induced by E. coli Endotoxin. Pulmonary surfactant activity test showed that the surface tension increased(P<0.01), SI、RI、Harea markedly decreased (P<0.05) Abnormality of the phospholipid content and activity of BALF played inportant role in the mechanism of acute lung injury.

关 键 词：急性 肺损伤 表面活性物质 肺功能 

分 类 号：R563.02[医药卫生—呼吸系统]