绝经前的健康女性中瘦体重、体脂含量和骨密度的关系  

Relationship between Lean Mass,Fat Mass and Bone Mineral Density in Healthy Premenopausal Females

作　　者：李远能[1] 陈湘定[1] 雷署丰[1] 邓红文[1] 

机构地区：[1]湖南师范大学生命科学学院教育部蛋白质化学和发育生物学重点实验室和分子与统计遗传学研究室,中国长沙410081

出　　处：《湖南师范大学自然科学学报》2007年第1期107-109,共3页Journal of Natural Science of Hunan Normal University

基　　金：国家自然科学基金重点资助项目(30230210)

摘　　要：从长沙地区的汉族人群中征集了878名年龄在20～45岁绝经前的健康女性样本，采用Hologic QDR4500W双能量X射线骨密度仪（DXA）来测量腰椎（L1.4）、髋部和全身其他部位的骨密度、瘦体重、体脂含量．应用SAS软件进行瘦体重和体脂含量与骨密度的Pearson相关分析和多元回归分析．发现瘦体重和体脂含量都与骨密度正相关，而且瘦体重对骨密度变异的贡献是8．0％～11．4％，体脂含量对骨密度变异的贡献是0．2％～2．5％．表明在绝经前的健康女性中，瘦体重是比体脂含量更加重要的决定骨密度变异的因素。878 healthy Premenopausal Chinese Han females aged 20 - 45 years were recruited in Changsha region. Bone mineral density （BMD） at the spine （L1,4）, total hip and whole body, fat mass and lean mass were measured by a Hologic 4 500 W dual-energy X-ray absorptiometry （DXA）. The pearson correlation analysis and multiple regression analyses were performed with fat mass and lean mass as independent variables and BMD as dependent variable while ad- justing for age and height. Lean mass and fat mass were positively associated with BMD. The effect of lean mass on BMD variation （8.0% - 11.4%） was evidently greater than that of fat mass （0.2% -2.5%）. Lean mass is a more important determinant of BMD than fat mass in healthy premenopausal Chinese females.

关 键 词：骨质疏松症 骨密度 体脂含量 瘦体重 

分 类 号：Q984[生物学—人类学] R589[医药卫生—内分泌]