壳聚糖妇科栓治疗念珠菌阴道炎、细菌性阴道病疗效观察  

Therapeutic observation of chitosan gynecologic suppository for candidal vaginitis and mycotic vaginitis

作　　者：郭琳[1] 

机构地区：[1]上海复旦大学附属妇产科医院妇科,上海200092

出　　处：《中国临床药理学与治疗学》2007年第2期236-240,共5页Chinese Journal of Clinical Pharmacology and Therapeutics

摘　　要：目的:观察壳聚糖妇科栓治疗念珠菌性阴道炎、细菌性阴道病的临床疗效。方法:采用随机对比性临床研究,将50例壳聚糖妇科栓治疗念珠菌阴道炎与50例达克宁栓治疗念珠菌阴道炎的疗效进行比较,将50例壳聚糖妇科栓治疗细菌性阴道病与50例甲硝唑栓治疗细菌性阴道病的疗效进行比较。结果:壳聚糖妇科栓治疗念珠菌阴道炎、细菌性阴道病的有效率分别为93.6%、79.1%,与常规药物达克宁栓、甲硝唑栓的治疗效果差异无统计学意义(P>0.05)。结论:壳聚糖妇科栓治疗念珠菌阴道炎、细菌性阴道病安全、有效,其优势是在无完善的实验室检查情况下,仍可对患者进行治疗,并且不易产生耐药性。AIM： To observe the clinical therapeutic effect of chitosan gynecologic suppository in the treatment of candidal vaginitis and bacteroidal vagina disease. METHODS： One hundred cases of candidal vaginitis were randomly divided into observation group （ n = 50） treated with chitosan gynecologic suppository and control group （ n - 50） treated with Daktarin suppository. Similarly, another one hundred cases of bacteroidal vaginitis were randomly divided into observation group （ n = 50） treated with chitosan gynecologic suppository and control group （ n = 50） treated with metronidazole suppository. The syndrome, physical sign and laboratory examination were compared before and after the treatment. RESULTS： The effective rates of the chitosan gynecologic suppository were 93.6 % and 79.1% for candidal vaginitis and bacteroidal vagina disease, respectively. There was no statistical difference in the effect between Daktarin suppository and metronidazole suppository （ P 〉 0.05 ）. CONCLUSION： Chitosan gynecologic suppository is safe, effective and more receptive for the patients, and the resistance is not easily produced for treatment of candidal vaginitis and bacteroidal vagina disease. Its advantage is that the patients can be treated without complete laboratory examination.

关 键 词：壳聚糖妇科栓 念珠菌阴道炎 细菌性阴道病 

分 类 号：R965.2[医药卫生—药理学] R711.73[医药卫生—药学]