依那普利预防阵发房颤复发的临床疗效  

Clinical Effects of Enalapril in Preventing Recurrence of Idiopathic Paroxysmal Atrial Fibrillation

作　　者：龚浩[1] 周胜华[1] 胡威[2] 彭宇镇[2] 

机构地区：[1]中南大学湘雅二医院 [2]湖南省长沙市第四医院,湖南长沙410006

出　　处：《医学临床研究》2007年第3期390-391,394,共3页Journal of Clinical Research

摘　　要：【目的】观察胺碘酮联合依那普利预防阵发房颤复发的疗效及对P波离散度(Pd)的影响。【方法】将52例阵发房颤病人随机分成A、B两组(每组26例),A组口服依那普利加胺碘酮,B组单服胺碘酮,随访6个月,每3个月作1次心电图(ECG)检测Pd及统计房颤发作情况。【结果】治疗3个月后两组Pd值与治疗前相比均明显降低(P<0.01),两组间的Pd值无统计学差异,6个月后两组病例的Pd值均进一步降低,A组下降程度较B组明显,两组间差异有显著性(P<0.01)。后3个月两组病例平均每人房颤发作次数及持续时间与前3个月相比均明显减少(P<0.01),A组减少程度较B组明显,两组间有显著性差异(P<0.01)。【结论】依那普利可能有预防阵发房颤复发的作用。[ObjectivelTo observe effects of amiodarone plus enalapril to prevent recurrence of idiopathic Paroxysmal atrial fibrillation（IPAF） and the change of P wave dispersion（Pd） . [MethodslA total of 46 patients with IPAF were randomly divided into GroupA（ n =26）, GroupB（ n = 26）. Patients in Group A received amiodarone plus enalapril , patients in Group B only received amiodarone. All patients were followed-up for six months and performed ECG test at baseline and 3,6 months after treatment , Pd was measured in resting 12-lead ECG. Onset times and persisting time of PIAF of everyone were recorded in 3,6 months after treatment, [ResultslAfter 3 months treatment , Pd was significantly decreased in both groups compared with pre-treatment,but no statistical significance between them, After 6 months treatment , Pd was further decreased in both groups , Group A was more obvious than Group B（ P〈0.01）. Latter 3 months compared with former 3 months, everyone mean onset times and persisting time in both groups were significantly reduced; Group A was more obvious than Group B（ P 〈0. 01）. [ConclusionlEnlapril can prevent recurrence of PIAF.

关 键 词：心房颤动/预防和控制 依那普利/治疗应用 

分 类 号：R541.75[医药卫生—心血管疾病]