超临界CO_2药物插嵌及在线检测研究进展  

Research progress of pharmaceutical impregnation in supercritical CO_2 condition and in-situ detection

作　　者：叶树明[1] 鲍成满[1] 蒋春跃[2] 

机构地区：[1]浙江大学生命科学学院,浙江杭州310058 [2]浙江工业大学化工与材料科学院,浙江杭州310024

出　　处：《化工进展》2007年第3期381-385,共5页Chemical Industry and Engineering Progress

基　　金：国家自然科学基金资助项目(No.20576123)

摘　　要：介绍了SC-CO2条件下药物插嵌的机理、过程以及插嵌过程中助溶剂的研究情况,阐述了目前SC-CO2条件下药物插嵌的在线检测方法,主要包括称重法、测量体积法以及光谱检测法,分析了影响在线检测的因素,并且综述了目前有关药物插嵌以及在线检测的研究现状。The mechanism and process of pharmaceutical impregnation, as well as cosolvent, in supercritical CO2 condition are introduced. On-line detection methods, especially weight measuring, volume measuring and in-situ spectroscopy are presented, The influence factors are also analyzed. The research progress in these fields is reviewed.

关 键 词：超临界CO2 药物插嵌 在线检测 

分 类 号：TQ46[化学工程—制药化工]