危重症患者胃肠激素水平变化及中西医结合治疗对其的影响  

Influence of combined treatment of traditional Chinese medicine and western medicine on gut hormone levels in patients with critical gastrointestinal dysfunction.

作　　者：赵平[1] 王蕊[2] 张秋才[3] 郭连澍[3] 陈宁[4] 

机构地区：[1]河北省人民医院ICU,石家庄050071 [2]河北医科大学中医学院 [3]河北省人民医院中医科 [4]保定市第三中心医院

出　　处：《中国综合临床》2007年第4期302-303,共2页Clinical Medicine of China

基　　金：河北省科技厅科技攻关项目（42761213）;河北省卫生厅科研基金资助项目（2004045）

摘　　要：目的 探讨危重症患者胃肠功能障碍时，胃肠激素水平的变化和中西医结合治疗对其的影响，以提高患者的存活率。方法 选择60例胃肠功能障碍患者，采用以中药为主的中西医结合治疗，于治疗前及治疗后测定血浆胃动素（MTL）、生长抑素（SS）、降钙素基因相关肽（CGRP）的水平。并与40例健康体检者作对照。结果 治疗组治疗前血浆MTL水平下降，与对照组比较差异有统计学意义（P〈0．01）；SS水平增高，与对照组比较差异有统计学意义（P〈0．01）。治疗组治疗前后比较MTL、SS水平差异均有统计学意义（均P〈0．01）；CGRP治疗前后比较及治疗前与对照组比较差异均无统计学意义（均P〉0．05）。结论 危重症患者胃肠功能障碍时血浆MTL分泌下降，SS分泌增高，致使胃肠运动及胃排空受到抑制，应用中西医结合治疗后，MTL上升、SS水平下降，胃肠运动功能恢复。Objective To understand the changes of blood gut hormone levels in the critical gastrointestinal dysfunction patients and also the influence of combined treatment of traditional Chinese medicine and western medicine. Methods 60 critical gastrointestinal dysfunction patients were treated with combined treatment of traditional Chinese medicine and western medicine. The levels of plasma motilin （ MTL）, somatostatin （ SS ）, calcitonin gene-related peptide （ CGRP ） were measured and then compared with normal control group of 40 cases. Results The levels of plasma motilin in treatment group were decreased with significant difference with control group （ P 〈 0.01）. The levels of plasma somatostatin in treatment group were significantly higher than control group （ P 〈 0.01）. The levels of plasma motilin and somatostatin in treatment group were significantly different after treatment （P 〈 0.01）. The levels of plasma calcitonin gene-related peptide in the treatment group and were not significantly different after treatment（ P 〉 0.05）, and also there was no significant differen cecompared with normal control group （ P 〉 0.05）. Condusion The critical gastrointestinal dysfunction patients are treated with combined treatment of traditional Chinese medicine and western medicine which can decrease the increased levels of plasma motilin ,increase the decreased levels of somatostatin, and prompt the gastrointestinal motility and evacuation.

关 键 词：胃肠功能障碍 胃肠激素 中西医结合 

分 类 号：R45[医药卫生—治疗学]