神经再生素对糖尿病大鼠周围神经病变治疗作用研究  

Effects of nerve regeneration factor on peripheral neuropathy of diabetic rats

作　　者：刘磊[1] 邵政一[1] 

机构地区：[1]南通大学医学院药理学教研室,南通226001

出　　处：《南通大学学报（医学版）》2007年第2期103-105,共3页Journal of Nantong University(Medical sciences)

摘　　要：目的:观察神经再生素对糖尿病大鼠周围神经病变的影响。方法:采用链脲菌素(STZ)糖尿病(DM)大鼠模型。造模成功1个月后给予药物处理,每日腹腔注射1次,连续给药8周。测定各组大鼠坐骨神经电生理及超微结构改变。结果:经神经再生素治疗后,糖尿病大鼠坐骨神经传导速度明显增快,感觉潜伏期(SL)减小,波幅升高,超微结构亦有明显改善。结论:神经再生素可改善神经髓鞘功能,有效提高糖尿病周围神经病变大鼠坐骨神经的感觉神经传导速度。Objective： To investigate the protective effects of NRF on peripheral neuropathy of diabetic rats. Methods： To use the model rats suffering from diabetes induced by Streptozotocin. The sensory nerve conduction velocity, stage of latency （SL） and amplitude of wave of sciatic nerve were determined with evoked electromyogram. The morphologic changes in diabetic neuropathy was observed with microscope and electro-microscope for 8 weeks. Results： It was shown that NRF was able to increase the sciatic nerve conduction velocity, reduce SL and increase wave amplitude significantly （P〈0.05）, and improve the morphologic changes in diabetic neuropathy effectively. Conclusion： NRF may have the beneficial effect on diabetic peripheral neuropathy. The results suggest that NRF is able to improve the nerve conduction velocity and improve the morphology of sciatic nerve of diabetic rats.

关 键 词：糖尿病 周围神经病变 神经再生素 大鼠 

分 类 号：R587.1[医药卫生—内分泌]