犬单剂量口服血塞通片的血浆药动学研究  

Study on pharmacokinetics of xuesaitong tablet after a single oral dose in dog plasma

作　　者：陈霞[1] 吴锋[2] 徐济良[2] 孟国良[2] 杨丽云[2] 

机构地区：[1]南通大学第二附属医院药剂科,南通226001 [2]南通大学医学院

出　　处：《南通大学学报（医学版）》2007年第2期115-116,120,共3页Journal of Nantong University(Medical sciences)

基　　金：南通市社会发展计划项目(S30009)

摘　　要：目的:研究血塞通片在犬血浆中的药动学。方法:6条犬单剂量口服血塞通片,采用高效液相色谱法测定血浆浓度。结果:达峰时间(tmax),峰浓度(Cmax),半衰期(t1/2)和曲线下面积(AUC)(0→4h)分别为56.7±5.2min,15.49±3.14ng/μl,55.66±13.64min和1543.93±157.07ng·min·μl-1。结论:本方法灵敏、简单、快速、专属性强,可满足临床药动学研究的要求。Objective ：To study the pharmacokinetics of xuesaitong tablet in dog plasma. Methods ：6 dogs received single-oral-dose xuesaitong tablets and plasma concentrations were determined by HPLC. Results ：The main pharmacokinetics parameters of xuesaitong tablets were that tmax was （56.7±5.2）min, Cmax was （15.49±3.14）ng/μL,t1/2 was （55.66±13.64）min, and AUC（0-4）was （1543.93±157.07）ng·min/μl. Conclusion：The method is highly sensitive, rapid, simple and specific enough to determine pharmacokinetics.

关 键 词：三七总皂苷 高效液相色谱法 药动学 血塞通片 血浆 

分 类 号：R969.1[医药卫生—药理学]