血清C反应蛋白对冠状动脉临界病变患者的临床预后价值  

The prognostic value of CRP in patients with intermediate coronary stenosis

作　　者：潘广杰[1] 娄书花[1] 薛书峰[1] 赵建华[1] 金军[1] 马惠芳[1] 田利平[1] 

机构地区：[1]洛阳市中心医院心内科,河南省471009

出　　处：《中国心血管病研究》2007年第4期276-277,共2页Chinese Journal of Cardiovascular Research

摘　　要：目的探讨血清C反应蛋白(CRP)对冠状动脉临界病变患者临床预后的价值。方法选择117例经冠状动脉造影提示临界病变的患者,测定其血清CRP,并按CRP水平分为高CRP组(CRP≥3mg/L)39例,正常CRP组(CRP<3mg/L)78例,比较1年内心性事件(包括顽固性心绞痛而行介入治疗、非致死性心肌梗死和心性死亡)的发生率。结果117例患者中高CRP组心性事件发生率明显高于正常CRP组(25.6%和2.6%,P<0.01),应用高CRP预测上述心脏事件的阴性和阳性预测值分别为97.4%和25.6%。结论血清CRP水平能预测冠状动脉临界病变患者1年间心性事件,可作为其危险分层的血清学指标。Objective To evaluate the progonistic value of C-reactive protein （CRP） in patients with intermediate coronary stenosis. Methods The plasma CRP levels in 117 patients with intermediate coronary stenosis were measured. They were divided into CRP elevated group （CRP ≥3 mg/L,n=39） and CRP normal group （CRP〈3 mg/L,n=78）. The evidence of myocardial damage including refractory angina, acute myocardial infarction and cardiac death were observed in the two groups in one year. Results The evidence of myocardial damage increased in CRP elevated group compared with CRP normal group （25.6% vs 2.6%,P〈0.01）.The negative predictive value of CRP elevated for evidence of myocardial damage was 97.4%, and the posiivite predictive value was 25.6%. Conclusion The study suggested that the plasma CRP can predicate the evidence of myocardial damage in one year of the patients with intermediate coronary stenosis, and could be as a marker for risk stratification in these patients.

关 键 词：C反应蛋白质 冠状动脉疾病 临界病变 心性事件 

分 类 号：R543.3[医药卫生—心血管疾病]