阑尾滤泡树突状细胞肉瘤的临床与病理  

Follicular dendritic cell sarcoma of the appendix： a case report

作　　者：沈丹平[1] 倪醒之[1] 吴志勇[1] 殷晓璐[2] 

机构地区：[1]上海交通大学医学院附属仁济医院普外科,200127 [2]上海交通大学医学院附属仁济医院病理科,200127

出　　处：《中华普通外科杂志》2007年第1期29-31,共3页Chinese Journal of General Surgery

摘　　要：目的 探讨阑尾滤泡树突状细胞肉瘤（follicular dendritic cell sarcoma,FDCS）的生物学行为特征,诊断要点和临床治疗.方法 对1例阑尾FDCS术后8个月腹腔内复发患者的手术标本进行病理形态学观察、免疫组化检测.结果 两次手术切除的肿瘤的组织病理学形态一致.免疫组化：CD21、CD35、S-100、Vimentin、CD68和FN呈阳性反应;CD117、CD34、SMA、Actin、NSE和CK呈阴性反应.病理学诊断：阑尾FDCS,腹腔内复发.结论 FDCS是一种非常罕见的肿瘤,大多发生于淋巴结,少数可见于淋巴结外.手术切除是治疗FDCS的主要方法.Objective To discuss the diagnosis of follicular dendritic cell sarcoma （FDCS） of the appendix, clinicopathologic features and the treatment. Methods A case of postoperative recurrent FDCS deriving from the appendix was reported. The pathological changes and immunohistocbemistry were evaluated. Results The histopathology of the specimen obtained from the recurrent tumor was identical with that of the first laparotomy. Immunohistochemically, the tumor cells were positive for CD21, CD35, S-100,Vimentin, CD68 and FN, and were negative for CD117, CD34, SMA, Actin, NSE and CK. The pathological diagnosis was local recurrent FDCS of the appendix within the abdomen. Condusions FDCS is a rare intermediate grade malignant tumor most often arising from lymph nodes and occasionally from extranodal regions. To date, approximately 90 FDCS cases have been reported in the literature. We reported the first case of FDCS arising from the appendix. FDCS is characteristically positive for CD21. Surgery seems to be the only effective therapy.

关 键 词：阑尾肿瘤 树突细胞 滤泡 免疫组织化学 

分 类 号：R686[医药卫生—骨科学]