促肝细胞再生磷酸酶3基因在胃癌组织中的表达及其临床意义  

Expression of phosphatase of regenerating liver-3 and its clinical implications in human gastric carcinoma

作　　者：李正荣[1] 詹文华[1] 何裕隆[1] 彭俊生[1] 蔡世荣[1] 马晋平[1] 

机构地区：[1]中山大学附属第一医院胃肠胰外科胃癌诊治中心,广州510080

出　　处：《中华普通外科杂志》2007年第2期130-132,共3页Chinese Journal of General Surgery

基　　金：国家自然科学基金资助（编号30571833）

摘　　要：目的探讨促肝细胞再生磷酸酶3（PRL-3）蛋白与胃癌的侵袭转移及预后的关系。方法采用免疫组化方法检测121例胃癌原发灶和95例淋巴结转移灶中PRL-3的表达，分析其表达水平与临床病理资料的关系及其对胃癌预后的影响。结果PRL-3在胃癌原发灶中表达的阳性率为71．9％，其中伴淋巴结转移原发灶的表达率（77．9％）明显高于无淋巴结转移的原发灶者（50．0％），两者之间差异有统计学意义（P=0．005）；淋巴结转移灶中PRL-3的表达率（91．6％）明显高于原发灶（77．9％），两者之间差异有统计学意义（P=0．009）。另外，PRL-3的表达与胃癌的淋巴管侵犯、淋巴结转移程度、TNM分期密切相关，并且与患者的预后呈负相关。结论PRL-3与胃癌的浸润转移密切相关，与患者的预后相关。Objective To investigate the expression of phosphatase of regenerating liver-3 （ PRL- 3 ） and evaluate its relationship with tumor invasion, metastasis and prognosis of human gastric carcinoma. Methods One hundred and twenty-one human gastric carcinoma specimens and 95 matched metastatic lymph nodes were studied. The expression of PRL-3 was detected by immunohistoehemistry and the relationship with clinicopathological parameters was analyzed. Results The overall PRL-3 expression was detected in 71.9% of primary gastric carcinoma specimens （77.9% in those with nodal metastasis, and 50% without nodal metastasis, P = 0. 005 ）. The incidence of PRL-3 expression in lymph node metastasis was significandy higher than that in primary gastric cancers （ P = 0. 009 ）. Moreover, PRL-3 expression was closely associated with lymphatic invasion, extent of lymph node metastasis, tumor stage and poor prognosis. Conclusion PRL-3 plays an important role in tumor invasion, metastasis and poor prognosis in gastric carcinoma.

关 键 词：胃肿瘤 肿瘤转移 基因表达 

分 类 号：R686[医药卫生—骨科学]