血液透析过程中尿毒症患者P波离散度的改变  

Changes of P wave dispersion during hemodiaiysis in uremia patients

作　　者：吕路[1] 崔小湖[2] 桓文穆[1] 黄锋先[3] 余祯[2] 黄华[1] 管红斌[1] 郑亚丽[4] 

机构地区：[1]广东药学院附属第一医院肾内科,广州510080 [2]广东药学院附属第一医院心电图室,广州510080 [3]中山大学附属第一医院肾内科,广州510080 [4]广东药学院附属第一医院心内科,广州510080

出　　处：《中国血液净化》2007年第3期138-139,共2页Chinese Journal of Blood Purification

基　　金：广东省医学科研基金(A2005513);广东省自然科学基金(06032273)

摘　　要：目的了解血液透析过程中尿毒症患者P波离散度(Pd)的改变。方法选择广东药学院附属第一医院肾内科患者血液透析前、血液透析2h及透析后测Pd,血液透析前用心脏彩超测量心脏的结构,血液透析前后测血尿素氮、肌酐和电解质。结果血液透析患者的Pd大于对照组,血液透析患者透析后的Pmax与Pd大于透析前,血液透析患者的左心房内径大于对照组。结论血液透析可使尿毒症患者的Pmax与Pd异常增大,检测Pd有助于防治血液透析患者房颤的发生。Objective To investigate the changes of P wave dispersion （Pd） during the hemodialysis in uremia patients. Methods Twelve-lead ECGs were recorded before hemodialysis, 2 hours after beginning hemoidalysis and after one hemodialysis session, then Pd was analyzed. Prior to hemodialysis, the left atrial structure was measured with echocardiography. Blood urea nitrogen, creatinin and ionic parameters were checked during the study. Results Pd of the uremic patients undergoing hemodialyis was larger than that of the control group. There were significant increase in P wave maximum duration （Pmax） and Pd at the end of one hemodialysis session. The left atrial diameter of the uremic patients undergoing hemodialyis was larger than that of the control group. Conclusion Hemodialysis can lead to abnormal increase of Pmax and Pd. Measurement of Pd is helpful for prevention and treatment of atrial fibrillation in uremic patients undergoing hemodialysis.

关 键 词：P波离散度 血液透析 尿毒症 

分 类 号：R318.16[医药卫生—生物医学工程]