有氧运动对衰老大鼠血清中抗氧化酶和过氧化脂质的影响  

Influence of aerobic exercise on blood serum antioxidant enzyme and lipid peroxidation in aged rats

作　　者：桑琛[1] 程珂玲[1] 王迪[1] 杭睿杰[1] 李明学[1] 

机构地区：[1]江苏大学医学院,江苏镇江212013

出　　处：《江苏大学学报（医学版）》2007年第2期128-130,共3页Journal of Jiangsu University：Medicine Edition

基　　金：镇江市社会发展基金资助项目(2005060)

摘　　要：目的:研究有氧运动对衰老大鼠血清中抗氧化酶和过氧化脂质的影响。方法:建立衰老大鼠模型,随机分为对照组和三组运动组,运动组分别给予每天0.5,1,2 h游泳训练,12周后检测血清中超氧化物歧化酶(SOD)、谷胱甘肽过氧化物酶(GSH-px)、过氧化氢酶(CAT)、丙二醛(MDA)、过氧化氢(H2O2)含量。结果:三组运动组的GSH-px含量明显大于对照组(P<0.01),各运动组间均有明显差异性,1 h运动组高于其他两组;0.5 h运动组的CAT含量明显大于对照组(P<0.05);三组运动组的MDA含量明显小于对照组(P<0.01);SOD,H2O2含量四组间没有明显差异性。结论:长期有氧运动训练可以增强抗氧化酶系统对氧自由基清除能力,减少对机体的氧化损害,以中低强度运动较为适宜。Objective： To investigate the effect of aerobic exercise on blood serum antioxidant enzyme and lipid peroxidation in aged rats. Methods： The rat aging models were randomly divided into control group and exercise groups which include 0.5h exercise group,lh exercise group and 2h exercise group. After 12 weeks, SOD, GSH-PX, CAT, MDA, H202 contents in blood were measured. Results： GSH-Px content increased in exercise groups. CAT content of 0.5h exercise group increased while compared with control group. MDA content decreased in exercise group. SOD and H202 had significant different. Conclusion： Long-time aerobic exercise can increase the level of antioxidant enzyme and decrease the injure of oxidation, the short and middle time exercise was more feasible.

关 键 词：有氧运动 衰老大鼠 血清 抗氧化酶 丙二醛 

分 类 号：R339.4[医药卫生—人体生理学]