有氧运动对心理应激衰老大鼠行为和氧自由基的影响  

Effect of aerobics on the behaviors and the free radical in peripheral blood of aging rats after being received psychological stress

作　　者：高炳俊[1] 胡治国 惠达[1] 曹瑛瑛[1] 王迪[1] 

机构地区：[1]江苏大学医学院,江苏镇江212013 [2]镇江市公安局,江苏镇江212001

出　　处：《江苏大学学报（医学版）》2007年第2期138-141,共4页Journal of Jiangsu University：Medicine Edition

基　　金：镇江市社会发展基金资助项目(2005060)

摘　　要：目的:研究有氧运动对心理应激衰老大鼠行为和外周血氧自由基的影响。方法:健康雌性SD大鼠28只,随机分为对照组、运动组、心理应激组、运动+心理应激组,实验后测定大鼠的开场行为和外周血自由基的变化情况。结果::①开场行为:在穿越格数上运动组、心理应激组、运动+心理应激组与对照组相比较均有显著的增加(P<0.05),在站立次数上心理应激组、运动+心理应激组与对照组及运动组相比较有显著减少(P<0.01)。②血清中SOD活性、H2O2含量:各组间均无明显差异性;MDA含量:运动组、运动+心理应激组与对照组及心理应激组相比较有明显的减少(P<0.05);过氧化氢酶(CAT)活性:运动组的CAT活性明显高于心理应激组(P<0.05);GSH-px活性:与对照组相比较,运动组、运动+心理应激组的活性明显增加(P<0.05),心理应激组则明显降低(P<0.05)。结论:不适宜的心理应激可对动物的自发行为和探究行为产生影响,并可诱发机体内自由基量的增加而导致机体损伤,而通过有氧运动可减轻心理应激对机体产生的影响。Objective. To investigate the effect of aerobics on the free radicals in peripheral blood of aging rats after being received psychological stress. Methods： Twenty eight healthy female SD rats were divided into four groups at random ：controlled（C） group, receiving swimming training for 60 mins（ S）, only getting psychological stress（ P）, receiving swimming training for 60 mins and psychological stress（ P ＋ S）. The open-field test and the oxygen free radicals in peripheral blood of SD rats were determined. Results： ① Compared with C group, the numbers of crossing in other groups were significantly higher （ P 〈 0.05 ） ; the numbers of rearing in P and P ＋ S group were significantly lower than that in C and P group （P 〈0.01 ）. ② the SOD activity and the H2O2 concentration in each group were no significant difference; compared with the C and P groups the MDA concentration in S and P ＋ S groups were significantly decreased （ P 〈 0.05 ） ; compared with the P group the CAT activity in S group were significantly increased （ P 〈 0.05 ） ; compared with the C group the activity of GSH-px in S and P ＋ S groups were significantly increased（ P 〈 0.05 ）, but the activity of GSH-px in P group were significantly decreased （ P 〈 0.05 ）. Conclusion： The unwell proper psychological stress can affect the self-moving behavior and the exploring behavior of the animal, and induce the increment of the free radicals inside the body which hurt the body; and the aerobics can alleviate the effect of the psychological stress in the body.

关 键 词：有氧运动 心理应激 衰老大鼠 开场行为 自由基 

分 类 号：R395.6[哲学宗教—心理学]