ZrCl_4/Hantzsch 1,4-dihydropyridine as a new and efficient reagent combination for the direct reductive amination of aldehydes and ketones with weakly basic amines  

作　　者：Zhen Gang Liu Nan Li Li Yang Zhong Li Liu Wei Yu 

机构地区：[1]State Key Laboratory of Applied Organic Chemistry, Lanzhou University, Lanzhou 730000, China

出　　处：《Chinese Chemical Letters》2007年第4期458-460,共3页中国化学快报（英文版）

基　　金：the National Natural Science Foundation of China （No. 20372030） for financial support.

摘　　要：ZrCl4/Hantzsch 1,4-dihydropyridine is a mild and highly efficient reagent combination for the direct reductive amination. Weakly basic amines such as anilines substituted by electron-withdrawing group and heteroaromatic amines can be reductively alkylated with electron rich aldehydes and ketones under mild conditions to form the secondary amines in excellent yields.ZrCl4/Hantzsch 1,4-dihydropyridine is a mild and highly efficient reagent combination for the direct reductive amination. Weakly basic amines such as anilines substituted by electron-withdrawing group and heteroaromatic amines can be reductively alkylated with electron rich aldehydes and ketones under mild conditions to form the secondary amines in excellent yields.

关 键 词：Zirconium tetractfloride Hantzsch 1 4-dihydropyfidine Reductive amination 

分 类 号：O623.731[理学—有机化学] O625.631[理学—化学]