血液灌流治疗儿童毒鼠强中毒血液中的毒物浓度监测  

Concentration determination of tetramine poisoning in children with hemoperfusion

作　　者：陈怡禄[1] 高岩[1] 卓仪[1] 朱丽萍[1] 李颖杰[1] 黄跃[1] 邓六勤[1] 欧阳珊[1] 叶红[1] 钟桴[1] 梁小丽[1] 

机构地区：[1]广东省广州市儿童医院,广东广州510120

出　　处：《儿科药学杂志》2007年第2期11-13,共3页Journal of Pediatric Pharmacy

摘　　要：目的:探讨应用血液灌流(HP)治疗儿童毒鼠强(TET)中毒血液中毒鼠强的毒物浓度监测。方法:应用HP治疗6例TET中毒的重症患儿;气相色谱(GC)法检测TET血中浓度。结果:TET中毒的重度患儿在HP治疗阶段与非HP治疗阶段,TET的代谢消除半衰期(t1/2)分别为(3.86±0.89)h(n=9,范围2.25～5.27h)和(90.19±92.21)h(n=5,范围35.40～253.39h)。结论:HP能安全、有效地治疗TET儿童中毒。TET中毒患儿在HP治疗时的t1/2明显变小,表明HP能加快TET从患儿体内排泄的速度。Objective：To determine the serum concentration of tetramine （TET） poisoning in children with hemoperfusion （HP）. Methods： The 6 cases were treated by he moporfusion. The concentrations of TET in plasma were determined by gas chromatography method （GC）. Results： The values of t1/2 of TET at hemoperfusion stages and no - hemoporfusion phases were （3.86 ± 0.89）h （ n = 9） and （90.19 ± 92.21 ）h （ n = 5）, respectively. Conclusions： The HP was safe and effective for treating TET poisoning in children. The results show that the t1/2 of TET has been remarkable decreased during hemoperfusion stages. The TET concentration - time curves show that the hemoperfusion could enhance the elimination of TET.

关 键 词：毒鼠强 中毒 儿童 血液灌流 临床毒代动力学 

分 类 号：R969.1[医药卫生—药理学]