阿奇霉素致儿童及青少年不良反应文献分析  

Literature analysis about adverse reactions to azithromycin in children and adolescents

作　　者：李琼[1] 邱继红[2] 

机构地区：[1]云南医学高等专科学校门诊部,云南昆明650031 [2]重庆市第七人民医院,重庆400054

出　　处：《儿科药学杂志》2007年第2期37-38,40,共3页Journal of Pediatric Pharmacy

摘　　要：目的:了解阿奇霉素致儿童及青少年不良反应的数量、类型、分布和特点。方法:检索维普中文科技期刊数据库1995年～2006年关于阿奇霉素不良反应的文献,筛选收集16岁以下(含16岁)青少年及儿童不良反应的案例报告,统计各病例的性别、年龄、给药方法、临床表现、不良反应出现时间和转归等,并进行总结分析。结果:不良反应以6岁以下学龄前儿童为主,占60%以上,不良反应出现时间较短,2h内出现者占一半以上,类型及临床表现呈多样化。结论:对阿奇霉素在儿科的临床应用要给予高度重视,以保障儿童用药安全。Objective： To learn the general pattern and characteristics of the ADRs associated with azithromycin to guide rational drug use. Methods： ADRs of azithromycin in 36 cases, reported in domestic medical journals during 1995-2006, were collected and analyzed. Results： ADRs of azithromycin often occurred in preschool children. The onset of ADRs was usually within 120 min after administration. ADRs could involve multiple organs and systems, and clinical manifestations and typos were various. Conclusions： Clinical physicians and pharmacists should pay more attention to the ADRs of azithromycin to assure rational drug use in children and adolescents.

关 键 词：药物不良反应 阿奇霉素 文献分析 儿童 

分 类 号：R961[医药卫生—药理学]