离子液体中KF作用下N-单取代磺酰胺的N-烷基化反应  

N-Alkylation Reaction of N-Monosubstituted Sulfonamides Promoted by Potassium Fluoride in Ionic Liquids

作　　者：胡燚[1] 康晖[1] 李恒[1] 韦萍[1] 

机构地区：[1]南京工业大学制药与生命科学学院,南京210009

出　　处：《应用化学》2007年第4期474-476,共3页Chinese Journal of Applied Chemistry

摘　　要：报道了KF作用下离子液体介质中N-单取代磺酰胺和卤代烃的N-烷基化反应,考察了4种不同结构的离子液体[Bmim]BF4、[Bpy]BF4和[Bpy]PF6对反应的影响。结果表明,以[Bmim]PF6为反应介质时显示出了最好的效果,反应的时间最短,收率最高。N-芳基或N-烷基单取代的磺酰胺和各类不同结构的活化的卤代烃和未活化的一级卤代烃在[Bmim]PF6中KF作用下,85℃反应2～10 h,以70%～97%的优良收率得到了13个N-烷基化产物,而且离子液体回收使用3次后效果未降低。实验结果表明,反应介质离子液体[Bmim]PF6和作为一种温和的碱KF有效地促进了烷基化反应的进行。The N-alkylation of N-monosubstituted suffonamides with alkyl halides promoted by KF using ionic liquids as reaction media was reported in this paper. Four different ionic liquids, [ Bmim ] BF4, [ Bpy ] BF4 and [ Bpy] PF6 were investigated, and [ Bmim ] PF6 showed the best effect when used as the reaction media, giving the highest yield in the shortest reaction time. Promoted by KF in [ Bmim] PF6, N-aryl or N-alkyl monosubstituted sulfonamides could react with various activated halides and unactivated primary halides smoothly. Reactions were performed at 85℃ for 2 ~ 10 hours, and thirteen N-alkylation products were obtained with 70% ~ 97% yields. Moreover, the ionic liquid recovered could be reused for three times with no appreciable decrease in yield and reaction rate. As demonstrated in this paper, both KF, which was used as mild base, and the ionic liquid [ Bmim ] PF6 promoted the alkylation reaction efficiently.

关 键 词：离子液体 磺酰胺 卤代烃 烷基化 氟化钾 

分 类 号：O621.3[理学—有机化学]