慢性束缚应激对小鼠全血铁锌钙镁含量的影响  

EFFECT OF CHRONIC RESTRAINT STRESS ON THE WHOLE BLOOD CONTENTS OF FE、ZN、CA AND MG IN RATS

作　　者：滕文锋[1] 施丽飞[1] 侯殿东[1] 孙卫民[1] 刘辉[1] 

机构地区：[1]大连医科大学检验医学院,大连116027

出　　处：《现代预防医学》2007年第7期1201-1203,共3页Modern Preventive Medicine

基　　金：国家自然科学基金资助项目(30370484)

摘　　要：[目的]通过观察慢性束缚应激后小鼠全血中铁、锌、钙和镁含量的变化,揭示慢性束缚应激反应对其全血中4种元素的影响和规律。[方法]建立小鼠慢性束缚应激模型,原子吸收分光光度法测定其全血中铁、锌、钙和镁的含量。[结果]正常对照组小鼠全血铁、锌、钙、镁含量(μg/ml)分别为:393.03±30.12,4.82±1.05,49.96±2.39,43.62±1.92;实验组小鼠全血铁、锌、钙、镁含量(μg/ml)分别为:291.72±83.57,3.62±1.24,59.53±8.97,40.31±5.31。与正常对照组比较,接受应激的小鼠全血中铁、锌显著降低,差异有统计学意义(P﹤0.05);血钙明显升高,差异有统计学意义(P﹤0.05);血镁降低,差异有统计学意义。[结论]慢性束缚应激使全血中铁、锌、镁降低,血钙明显升高。元素铁、锌、钙与慢性束缚应激反应之间存在一定的联系。[Objective] To observe the changes of whole blood contents of Fe, Zn, Ca and Mg in rats under chronic restraint stress, and study the effect and regularity of chronic restraint stress on whole blood contents of the four elements. [Methods] Chronic restraint -stressed model in rats was established, and whole blood contents of Fe, Zn, Ca and Mg in rats were determined by AAS. [ Results] Whole blood contents of Fe, Zn, Ca and Mg in rats in control group were as follows （μg/ml） ： 393.03±30.12, 4.82±1.05, 49.96±2.39, 43.62±1.92, respectively, and that in experinaental group were as follows （μg/ml） ： 291.72±83.57, 3.62±1.24, 59.53±8.97, 40.31±5.31, respectively. The whole blood contents of Fe, Zn decreased significantly compared with the control group （P 〈 0.05） , the contents of Ca increased significantly. （P 〈 0.05） and the contents of Mg decreased. There were statistical differences between the two groups. [ Conclusion] Chronic restraint stress can decrease whole blood contents of Fe, Zn and Mg, while increase the contents of Ca. There is some association between elements Fe, Zn, Ca and chronic restraint stress .

关 键 词：应激 动物研究 铁 锌 钙 镁 

分 类 号：R285.5[医药卫生—中药学]