静脉吸毒人群3年随访的HIV新发感染率和保持率研究  

HIV INCIDENCE AND FACTORS CONTRIBUTED TO RETENTION IN A 36-MONTH PROSPECTIVE COHORT STUDY AMONG INJECTION DRUG USERS

作　　者：邢志惠 尹潞[2] 刘莉[1] 阮玉华[2] 朱玉[1] 黄建萍[1] 曹晓蕴[2] 张莉[2] 郝春[2] 胡薇[1] 陈康林[1] 秦光明[3] 邢辉[2] 洪坤学[2] 邵一鸣 

机构地区：[1]四川省凉山州西昌市皮肤病性病防治站,西昌615000 [2]中国疾病预防控制中心性病艾滋病预防控制中心和传染病预防控制国家重点实验室 [3]四川省疾病预防控制中心

出　　处：《现代预防医学》2007年第7期1228-1230,1233,共4页Modern Preventive Medicine

基　　金：国家十五科技攻关课题项目(2004BA719A01);国家自然科学基金项目(30571612;10501052);卫生部艾滋病防治应用性研究项目(WA2003-13);全球基金第四轮中国艾滋病项目应用性研究项目(2005GF4RW002)

摘　　要：[目的]了解静脉吸毒人群前瞻性研究队列3年随访的HIV血清抗体阳转率和队列保持率情况。[方法]于2002年11月,在四川省西昌市从社区招募了HIV血清抗体阴性的静脉吸毒人群前瞻性研究队列333人,队列每6个月随访1次并采集血样进行HIV抗体检测,以及分析队列本底的社会人口学和HIV高危行为特征与队列保持率的关系。[结果]静脉吸毒人群研究队列3年随访的HIV新发感染率为2.26/100人年(95%CI:1.08～3.45)和保持率为68.8%(229/333)。在多因素logistic回归模型分析中,与队列保持率的关系有统计学意义的变量为:彝族(OR:0.35;95%CI:0.21～0.59;P﹤0.0001)、6个月回访(OR:3.10;95%CI:1.81～5.31;P﹤0.0001)和近3个月静脉吸毒频率高(OR:1.79;95%CI:1.00～3.19;P=0.0485)。[结论]本研究结果表明该地区静脉吸毒人群HIV新发感染率较高,彝族和6个月未随访到的静脉吸毒人群队列保持率低。[Objective] To investigate the HIV seroconversion, as well as cohort retention and the contributed factors in a 3-year follow-up study among injection drug users （IDUs） . [Methods] In November 2002, a community-based baseline survey was conducted to recruit 333 HIV-seronegative IDUs for a prospective cohort study in Xichang County of Sichuan Province, China. Follow-up visits were conducted every 6 months to analyze risk factors such as sociodemographic and behavioral characteristics at baseline associated with cohort retention, and blood specimens were also collected to test for antibodies against HIV. [ Results] During the 36-month follow-up period, HIV incidence and cohort retention rate were 2.26 per 100 person-years （95% confidence interval [CI] ： 1.08-3.45） and 68.8%, respectively. Multivariate Logistic regression model showed that risk factors significantly associated with cohort retention included Yi Nationality （OR： 0.35; 95%CI： 0.21-0.59; P〈 0.0001）, callback after 6 months （OR： 3.10; 95%CI： 1.81-5.31 ; P〈 0.0001）, and drug injection in the past 3 months （OR： 1.79; 95%CI： 1.00-3.19; P = 0.0485） . [Conclusion] HIV seroconversion is high in this area and cohort retention of Yi Nationality or IDUs with no callback at 6th month was low.

关 键 词：静脉吸毒人群 前瞻性研究队列 保持率 HIV 新发感染率 高危行为 

分 类 号：R512.91[医药卫生—内科学]