泰脂安胶囊治疗高脂血症性脂肪肝的实验研究  

Experimental study on treating hyperlipidemic fatty liver with Taizhi'an capsule

作　　者：孙梅[1] 单建贞[1] 张国平[1] 应华忠[2] 

机构地区：[1]浙江大学医学院附属二院,浙江杭州310009 [2]浙江中医药大学,浙江杭州310053

出　　处：《中国中药杂志》2007年第7期616-619,共4页China Journal of Chinese Materia Medica

基　　金：浙江省中医管理局资助项目(2005C081)

摘　　要：目的:观察调脂药泰脂安胶囊对高脂血症性脂肪肝的治疗作用。方法:采用高脂饮食喂饲大鼠8周,诱导高脂血症性脂肪肝模型,实验分为泰脂安高、中、低(1 000,500,250 mg.kg-1)剂量组、易善复对照组、模型组和正常组,检测各组肝指数、肝功能、血脂、肝脂、肝组织超氧化物歧化酶(SOD)、丙二醛(MDA)含量及肝组织学改变。结果:高脂血症性脂肪肝模型组肝指数、血脂、肝功能、肝脂显著升高(P<0.001),肝组织SOD明显下降(P<0.05),肝组织学轻中度脂肪变;泰脂安高、中剂量组血脂、肝功能均显著下降(P<0.001),肝脂明显下降(P<0.001,P<0.05),肝组织SOD明显升高(P<0.05),肝组织学接近正常。结论:泰脂安胶囊可安全有效的用于高脂血症性脂肪肝的治疗。Objective： To observe the effects of Taizhi＇an capsule in treatment of hyperlipidemic fatty liver. Method. The model rats were induced by feeding high caloric diet for 8 weeks, then fifty rats were randomly divided into five groups, and each group had ten rats, the Taizhi＇an groups （high dose 1 000 mg · kg^-1 , middle dose 500 mg· kg^-1 , low dose 250 mg · kg^-1 ）, the Yishanfu group and the model group. Liver index （liver weight/body weight）, liver function, blood lipid, liver lipid, the content of MDA and SOD in liver were assayed after therapy, and observe Pathologic changes in rats＇liver. Result： Liver index, blood lipid, liver lipid, liver function increased significantly （P 〈0. 001 ） in model rats, and the content of SOD in liver decreased significantly （P 〈0. 05 ）, Liver histology expressed mild to moderate fat denaturation; After being treated with high and middle dose of Taizhi＇an capsule for six weeks, blood lipid, liver function decreased significantly （P 〈0. 001 ）, and liver lipid decreased significantly （P 〈0. 001, P 〈0. 05） , the content of SOD in liver increased significantly （ P 〈 0. 05 ）, meanwhile liver histology was closed to normal. Conclusion： Taizhian capsule is effective in the treatment of hyperlipidemic induced fatty liver.

关 键 词：高脂血症 脂肪肝 泰脂安胶囊 

分 类 号：R285.5[医药卫生—中药学]