新型促渗剂壬代环戊双醚对丹参凝胶透皮吸收的影晌  

Effects of 2-n-nonyl-1,3-dioxolane as an enhanceron transdermal absorption of Salvia miltiorrhiza gel

作　　者：沙玫[1] 尹莉芳[2] 徐伟[1] 陈玉枝[1] 

机构地区：[1]福建中医学院药学系,福建福州350108 [2]中国药科大学药剂教研室,江苏南京210009

出　　处：《中国中药杂志》2007年第6期487-489,共3页China Journal of Chinese Materia Medica

基　　金：福建省教育厅课题(JA04216)

摘　　要：目的:探讨不同浓度新型促渗剂壬代环戊双醚对丹参凝胶的透皮吸收影响。方法:采用改良Frans扩散池进行体外透皮吸收实验,高效液相色谱法检测丹参酮ⅡA。结果:壬代环戊双醚含量在4.0%时透皮吸收最好。结论:壬代环戊双醚具有较好的促渗作用,是较好的新型促渗剂。Objective： To choose the most suitable concentration of 2-n-nonyl-1,3-dioxolane as a penetration enhancer in tanshinone gel preparation. Method： In vitro, transdermal absorption was studied using improved Frans equipment and rats skin. Tanshinone ⅡA was tested by HPLC. Result： The 4.0% concentration of 2-n-nonyl-1, 3-dioxolane enhanced the transdermal absorption significantly in the preparation. Conclusion： 2-n-nonyl-1, 3-dioxolane was a new effective permeaton enhancer.

关 键 词：壬代环戊双醚 丹参酮ⅡA 渗透促进剂 新辅料 

分 类 号：R283[医药卫生—中药学]