决明子蛋白质和蒽醌苷对D-半乳糖衰老小鼠学习记忆及代谢产物的影响  

Effect of protein and anthraquinone glucosides from Semen Cassia on learning and memory capacity and related substances of senile mice induced by D-galactose

作　　者：刘金珠[1] 林湘[1] 李续娥[1] 郭宝江[1] 

机构地区：[1]华南师范大学生命科学学院,广东广州510631

出　　处：《中国中药杂志》2007年第6期516-519,共4页China Journal of Chinese Materia Medica

摘　　要：目的:观察决明子蛋白质和蒽醌苷对D-半乳糖所致衰老小鼠学习记忆与相关酶及代谢产物的影响。方法:选用长期皮下注射D-半乳糖形成的衰老小鼠模型。结果:三等分辐射式迷宫(即Y-迷宫)及一次性被动回避反应测试,证实决明子蛋白质和蒽醌苷对衰老小鼠的学习记忆障碍有显著的改善作用;决明子蛋白质和蒽醌苷可显著降低衰老小鼠脑组织中脂质过氧化产物丙二醛(MDA)的含量、提高脑组织超氧化物岐化酶(SOD)水平和减少肝组织中脂褐素(LF)含量。决明子蛋白质尚能显著降低衰老小鼠脑组织中单胺氧化酶(MAO)含量。结论:决明子蛋白质和蒽醌苷具有抗衰老及促进学习记忆能力的作用。Objiective： To investigate actions of protein and anthraquinone glucosides from Semen Cassia on learning and memory capacity and related substances of senile mice induced by D-galactose. Method： The subacute senile mouse models induced by injection of D-galactose subcutaneously were used. Result： Protein and anthraquinone glucosides from Semen Cassia could improve the learning and memory capacity of senile mice. Protein and anthraquinone glucosides from Semen Cassia not only inhibited the increase of malondialdehyde （MDA） in cerebrum of senile mice, but also enhanced the level of superoxide dismutase （SOD） in cerebrum and lessened the lipofuscin （LF） in liver tissue of senile mice. Protein from Semen Cassia could reduce the content of monoamine oxidase （MAO） in cerebrum of senile mice. Conclusion： Protein and anthraquinone glucosides from Semen Cassia could improve the learning and memory capacity of senile mice and delay aging.

关 键 词：决明子 蛋白质 蒽醌苷 抗衰老 

分 类 号：R285.5[医药卫生—中药学]