前列地尔脂微球载体注射液对糖尿病下肢动脉血管病变的影响  

Effects of Lipo-PGE1 on the Lower Limb Blood Vessel in Diabetic Patients.

作　　者：李静宜[1] 李强[1] 王薇[1] 孙予倩[1] 梁玮[1] 张巾超[1] 

机构地区：[1]哈尔滨医科大学附属第二医院内分泌科,黑龙江哈尔滨150086

出　　处：《中国实用内科杂志》2007年第8期597-599,共3页Chinese Journal of Practical Internal Medicine

基　　金：黑龙江省卫生厅科研课题(2004-149)

摘　　要：目的观察前列地尔脂微球载体注射液(Lipo-PGE1)对糖尿病下肢动脉血管病变的影响。方法选取哈尔滨医科大学附属第二医院内分泌科2004年10月至2005年6月住院的2型糖尿病下肢动脉血管病变患者36例,采用Lipo-PGE1治疗,观察治疗前后股动脉、腘动脉、胫后动脉和足背动脉的内径和血流量。结果糖尿病下肢动脉血管病变经Lipo-PGE1治疗后,股动脉、腘动脉、胫后动脉和足背动脉内径均增加,胫后动脉和足背动脉内径在治疗前后差异有显著性意义(P<0.05及P<0.01)。股动脉、腘动脉、胫后动脉和足背动脉血流量在治疗后均增加,但差异无显著性意义。经Lipo-PGE1治疗后,36例受试者均自我感觉行走有力,有间歇性跛行的18例患者无瘤行走距离和最大耐受行走距离均明显增加。结论Lipo-PGE1对糖尿病下肢动脉血管病变具有肯定的治疗作用。其可以扩张股动脉、腘动脉、胫后动脉和足背动脉的内径,增加其血流量,但是其最主要的靶向部位在胫后动脉和足背动脉,扩张这些较小的肢端动脉,可有效改善症状。Objective To evaluate the effects of Lipo prostaglandin E1 （ Lipo-PGE1 ） on the lower limb blood vessel in diabetic patients. Methods The study was performed in 36 patients with diabetes related lower limb vascular disease. Before and after Lipo-PGE1 treatment for 28 days, vascular diameter and blood flow velocity of femoral artery, popliteal artery, posterior tibial artery and dorsal pedal artery were measured by Doppler ultrasonography examination. Results After the treatment with Lipo-PGE1, the vascular diameters of femoral artery, popliteal artery, posterior tibial artery and dorsal pedal artery were dilated;and there were significant differences in posterior tibial artery and dorsal pedal artery. After the treatment with Lipo-PGE1, blood flow velocity of femoral artery ,popliteal artery ,posterior tibial artery and dorsal pedal artery were increased, however, there were no significantly statistical differences. After the treatment with Lipo-PGE1 ,all the patients feel well. Painless walking distance and maximal walking distance of 18 patients with intermittent claudication were increased. Conclusion Lipo-PGE1 causes a significant improvement of diabetes related lower limb vascular disease. Furthermore, the results demonstrated the major effects on posterior tibial artery and dorsal pedal artery. Lipo-PGE1 can di- late the smaller artery, which is important and helpful for patients to improve symptoms and signs.

关 键 词：前列地尔 前列地尔脂微球载体 糖尿病 下肢血管 

分 类 号：R5[医药卫生—内科学]