联合检测抗环瓜氨酸肽抗体及抗角蛋白抗体在类风湿关节炎患者中的临床意义  

The Clinical Value of Anti-cyclic Citrullinated Peptide Antibody and Anti-Keratin Antibody in Rheumatoid Arthritis

作　　者：王永福[1] 康丽荣[1] 张文兰[1] 吴昆[1] 李青[1] 高岚[1] 常志芳[1] 

机构地区：[1]包头医学院第一附属医院风湿免疫科,内蒙古包头014010

出　　处：《内蒙古医学杂志》2007年第2期131-132,共2页Inner Mongolia Medical Journal

摘　　要：目的:通过比较抗环瓜氨酸肽抗体(Anti-CCP)、抗角蛋白抗体(AKA)和类风湿因子(RF)在类风湿关节炎(RA)中的敏感性及特异性,来探讨三者联合检测在RA中的意义。方法:应用酶联免疫吸附试验(ELISA)检测80例RA患者、60例非RA患者抗环瓜氨酸抗体和抗角蛋白抗体,同时应用乳胶凝集试验检测RF,对结果进行统计比较。结果:Anti-CCP和AKA的检测灵敏度与RF接近,但二者的特异性均高于RF。Anti-CCP和AKA在RA患者中的检出率分别为42.5%和43.8%,但在RF阳性的RA患者中,Anti-CCP和AKA的检出率为71.1%和68.4%,显著高于RF阴性组的检出率16.7%和21.4%(P<0.01)。结论:Anti-CCP和AKA是检测RA的一项特异性较高的血清学指标,且可以作为RA的早期诊断指标。Objective： To Compare the sensitivity and specificity of anti- cyclic citrullinated peptide antibody （anti - CCP） anti- keratin antibody （anti - AKA） and rheumatoid factor CRF in rheumatoid ＂ar thritis （RA）, for exploring the significance of combined determination of anti - CCP, anti - AKA and RF in RA. Methods： In 81 cases with RA and 60 cases Without RA, the levels of anti - CCP and anti - AKA Were determined by ELISA method and RF was de termined by latex agglutination test. The results were statistically compared. Results： The sensitivity and anti - CCP and AkA was similar to that of RF, but their specificity was higher than that of PF The detective rate of anti - CCP and AKA in RA patients was respectively 42.5 % and 43.8 %, which was higher in RA patients with positive RF than that in ones with negative RF （71.1% vs 16. 7 % ; 68.4 % vs 21.4 % ; P 〈 0.01）. Conclusion： Anti - CCP and AKA are sensitive in detecting PA. They may be index for early diagnosis of RA.

关 键 词：类风湿关节炎 抗环瓜氨酸肽抗体 抗角蛋白抗体 

分 类 号：R446.61[医药卫生—诊断学] R593.22[医药卫生—临床医学]