Tourette综合征的发病危险因素分析  

An analysis of the risk factors of Gilles de la Tourette syndrome

作　　者：徐惠琴[1] 金嵘[2] 郑荣远[1] 张磊[1] 邵蓓[1] 何金彩[1] 王旭华[1] 

机构地区：[1]温州医学院附属一院神经内科,浙江温州325000 [2]温州医学院附属一院流行病学教研室,浙江温州325000

出　　处：《中国实用儿科杂志》2007年第3期196-198,共3页Chinese Journal of Practical Pediatrics

基　　金：浙江省教育委员会科研基金资助项目(基金编号:981154)

摘　　要：目的探讨Tourette综合征(TS)发病的危险因素。方法2000-01—2004-12采用病例对照研究的方法,对温州医学院附属一院100例TS患儿及100名对照病例的相关资料进行非条件Logistic回归和主成分分析。结果非条件Logistic回归多因素分析显示,该病有统计学显著性意义的危险因素是TS家族史、注意缺陷伴多动障碍(ADHD)、过敏性哮喘、母亲孕早期受精神刺激、高热(T>39℃)和极低频磁场暴露,其标准回归系数分别为1.3987、3.6385、1.7657、1.7250、1.8973和1.0677。主成分分析提取了4个主成分,其方差累积贡献率为57.025%。结论TS的发病与遗传因素和环境因素有关。Objective To explored the risk factors of Gilles de la Tourette syndrome（TS）. Methods Totally 100 cases with TS and 100 controls were investigated through case-control study. Data was analyzed with non-conditional logistic regression and principal component analysis, Results Results from non-conditional logistic regression showed that such cases were associated with following factors：family history of TS, attention deficit hyperactivity disorder （ADHD）, allergic asthma, nocuous mental stimulation during early pregnancy,high fever（ T 〉 39℃ ）, exposure to pole low frequent electro- magnetism field. The standard regression coefficients were 1. 3987,3. 6385,1. 7657,1. 7250,1. 8973 and 1. 0677,respectively. Four principal components were extracted through principal component analysis, and the cumulative contribution Of variances of the 4 principal components was 57. 025%. Conclusion The risk factors of TS are related to the concomitance of genetic factors and environmental factors.

关 键 词：TOURETTE综合征 危险因素 非条件LOGISTIC回归 主成分分析 

分 类 号：R72[医药卫生—儿科]