地方性氟病发病区胎儿肝细胞体视学参数的观测  

StereologicalStudyontheHepatocytesofFetusesfromFluorosisEndemia

作　　者：于燕妮[1] 刘家骝[1] 董仲[1] 万昌武[1] 肖开棋[1] 

机构地区：[1]贵阳医学院病理教研室

出　　处：《中华物理医学杂志》1996年第1期33-35,I005,共4页Chinese Journal of Physical Medicine and Rehabilitation

摘　　要：对地方性氟病区引产胎儿肝细胞进行体视学观测。结果发现，与非病区胎儿相比，发病区孕妇所生胎儿骨氟含量明显升高，差异有显著性（Ｐ＜０．０５）；电镜观察其肝细胞发现：肝细胞线粒体肿胀、嵴断裂，线粒体平均周长、平均体密度、平均截面积及平均体积均明显增大，差异有显著性（Ｐ＜０．０５）。Thehepatocytesofhumanfetusesfromanendemic-fluorosisregionwerestudiedwithstere-ologicalmethod.Theresultsshowedthatthecententsofthebonefluorideofpregnantwomenfromanen-demicfluorosisregionweremarkedlyincreasedincomparisonwithonesinthenon-diseaseregion.Ultra-structuraly,thehepatocyticmitochondriaofthefetuseswereswelanddissolving.Thevaluesofaverageperimeter,averageareaandaveragevolumeofthemitochondriaweremarkedlyincreased.Theresultssug-gestthattheexcessivefluoridemaybringaboutdamagetothehepatocyticmitochondriaofhumanfetusesfromanendemic-fluorosisregion.

关 键 词：氟病 胎儿 肝细胞 体视学 氟中毒 肝脏损伤 

分 类 号：R595.9[医药卫生—内科学]