肝硬变患者胃冠状静脉壁生长因子对胃冠状静脉构形改建的影响  

The Effect of Growth Factors on Gastric Coronary Vein Remodeling during Hepatic Cirrhosis

作　　者：杨镇[1] 田磊[1] 裘法祖[1] 恩巴.恩巴 

机构地区：[1]同济医科大学附属同济医院外科

出　　处：《同济医科大学学报》1996年第3期216-218,T252,共3页Acta Universitatis Medicinae Tongji

基　　金：国家目然科学基金资助项目(No.39470685)

摘　　要：采用免疫组织化学技术,研究血小板源性生长因子(PDGF)、碱性成纤维细胞生长因子(bFGF)、表皮生长因子(EGF)和转化生长因子α(TGFα)在肝硬变(n=30)和非肝硬变患者(n=10)胃冠状静脉壁的表达与分布.结果:肝硬变患者的强阳性检出率分别为93%、89%、70%和68%,非肝硬变者均为0.提示肝硬变门静脉高压症时,门静脉系统的血管壁可产生多种生长因子,并以旁分泌和自分泌方式作用于血管本身,引起血管构形改建和功能障碍.为生长因子阻断/拮抗疗法用于防治血管构形改建提供理论基础.The purpose of the present study is to analyse the expression and localization of PDGF, bFGF, EGF, TGFα in gastric coronary veins of cirrhotic and non-cirrhotic patients with immunohistochemistry technique. The strong positive rates were 93%, 89%, 70% and 68% respectively in cirrhotic patients (n=30), and 0% in non-cirrhotic patients (n -10). It is concluded that the portal vein system could produce growth factors during cirrhosis , and then the growth factors could act on the portal vein system by autocrine and paracrine, resulting in vascular remodeling and disturbance of its function. It is clear that this experiment gives fresh insight into the growth factor blocker/antagonist treatment of vascular remodeling.

关 键 词：生长因子 肝硬变 门静脉 冠状静脉 构形 

分 类 号：R575.310.2[医药卫生—消化系统] R322.123[医药卫生—内科学]