肌酸代谢动力学研究进展  

Research Progress on the Pharmacokinetics of Creatine

作　　者：练艺影[1] 曹建民[2] 邓艳香[3] 石鸿儒[4] 

机构地区：[1]天津医科大学体育部,天津300070 [2]北京体育大学,北京100084 [3]广西大学体育部,广西南宁530004 [4]河北师范大学体育学院,河北石家庄050000

出　　处：《北京体育大学学报》2006年第12期1672-1674,共3页Journal of Beijing Sport University

摘　　要：现已发现肌酸进行跨膜转运需要相应的转运体(包括细胞膜运载体和线粒体运载体)是肌酸在体内分布的关键因素之一;肌酸的转运与转运体的数量及其表达、骨骼肌纤维的类型、Na+和Cl-浓度、激素、运动等多因素相关;肌酸在机体内代谢并分解为肌酸酐并且经肾脏排除体外;肌酸代谢动力学研究涉及到血药最大浓度(Cmax)和达到最大浓度的时间(Tmax)等动力学参数。The result shows that it is known that there are two main kinds of Cr transporters （CrTs）, one is plasmalemma CrT and the other is mitochondrial CrT which affects the distribution of Cr. Cr uptake across the plasma membrane by CrT relating to the quantity of CrT and its expression, different skeletal muscle fiber types, the of Na ^＋ and Cl^-, hormone, exercises and so on. Cr is converted into creatiulne（Crn） that constantly diffuses out of the tissues into the blood and is excreted by the kidneys into the urine. Some researches on pharmacokinetics has examined the behaviors of Cr in blood, such as a concentration of maximal plasma （Cmax） and a time of maximal plasma （Tmax）.

关 键 词：肌酸 磷酸肌酸 转运体 代谢 药物代谢动力学 运动 

分 类 号：G804.7[文化科学—运动人体科学]