氯诺昔康在乳腺区段切除手术中的应用  

The Clinic Application of Lornoxicam to Patients Undergoing Segmental Mastectomy

作　　者：柯炳峰 吴先平[2] 

机构地区：[1]佛山市顺德中西医结合医院药剂科,广东佛山528333 [2]佛山市顺德中西医结合医院麻醉科,广东佛山528333

出　　处：《实用临床医学（江西）》2007年第3期53-55,共3页Practical Clinical Medicine

摘　　要：目的：探讨氯诺昔康用于乳腺区段切除手术麻醉的有效性及安全性。方法：择期乳腺区段切除手术患者66例，麻醉方式以局麻为主，随机分为氯诺昔康组（n=33）和对照组（n=33）。在切皮前20～30min氯诺昔康组给予氯诺昔康16mg静脉注射，而对照组给予生理盐水4mL静脉推注。临床效果评价标准：（1）视觉模拟（VAS）评分；（2）局麻药和芬太尼的用量；（3）患者对术中镇痛效果总体印象（VRS）评分；（4）术中呼吸循环指标Ramsay镇静评分；（5）术后24h内不良反应（如恶心呕吐）发生情况。结果：与对照组比较，氯诺昔康组术中血流动力学稳定，术中VAS评分较低，局麻药和芬太尼用量及加药次数显著减少，术后恶心呕吐等不良反应少。结论：氯诺昔康用于乳腺区段切除手术可以提供满意的镇痛效果。Objective：To assess the analgesia efficacy and safety of lornoxicam in patients undergoing segmental mastectomy. Methods： Sixty-six patients, scheduled for segmental mastectomy were randomly divided into lornoxicam group and control group. All patients received local analgesia. Lornoxicam 4 mL （16 mg） in lornoxicam group and 0.9% Sodium Chloride 4 mL in control group were injected intravenously 30 minutes before operation. The clinic effects were assessed by. （1） VAS score; （2） volume and frequency of local analgesia drugs and fentanyl; （3） Patients overall impression of treatment; （4） Indexes of respiratory and circulation system Ramsay sedation scale; （5） Adverse effects such as nausea and vomiting up to 24 h after operation. Results. Compared with control group, VAS score, volume and frequency of analgesia drugs and fentanyl, adverse effects such as nausea and vomiting were decreased markedly, and the indexes of hemodynamics kept stable in lornoxicam group. Conclusion. Lornoxicam could provide enough analgesic efficacy for patients undergoing segmental mastectomy.

关 键 词：氯诺昔康 镇痛 乳腺区段切除术 

分 类 号：R971.2[医药卫生—药品]