急性冠脉综合征病人D-二聚体和C反应蛋白的变化及其临床意义  

The D-dimer and C-reactive Protein in Patients with Acute Coronary Syndrome

作　　者：葛长江[1] 周安荣[1] 房秀丽[1] 邱杰夫 刘永明[1] 

机构地区：[1]江苏省连云港市第三人民医院

出　　处：《中西医结合心脑血管病杂志》2007年第4期288-289,共2页Chinese Journal of Integrative Medicine on Cardio-Cerebrovascular Disease

基　　金：江苏省连云港市卫生局基金资助项目(No.05057);江苏省连云港市科技局基金资助项目(No.ZD2005002)

摘　　要：目的探讨急性冠脉综合征（ACS）病人血浆D-二聚体（DID）和C反应蛋白（CRP）水平的变化及其临床意义。方法58例ACS病人、30例稳定型心绞痛病人和30名健康体格检查者为研究对象，采用Nyeo Card胶体金标法检测观察者静脉血中的DD含量，Nyeo Card单人份金标法检测观察者静脉血中CRP水平，并行相关性分析。结果ACS组血浆DD、CRP分别为（1．48±0．45）mg／L、（13．3～36．2）21．4mg／L明显高于稳定型心绞痛组[（0．31±0．13）mg／L、（1．1～9．6）5．2mg／L]TL对照组[（0．26±0．12）mg／L、（0．9-8．4）4．9mg／L]（P〈0．01）。ACS组血浆DO含量与CRP水平间呈显著的正相关（r=0．721，P〈0．01）。结论血浆DD含量和CRP水平可作为早期预测急性冠脉综合征的生化指标。Objective To study the changes and clinical significance of plasma D- dimer and C- reactive protein in patients （pts） with acute coronary syndrome （ACS）. Methods Fifty-eight hospitalized pts with ACS was as the study group, 30 hospitalized patients with stable angina pectoris （SAP） and 30 normal subjects as the control. The D- dimer was tested dynamically by NycoCard ELISA methods. The C- reactive pmtdn was tested dynamically by Nyco Card CRP methods. Results D - dimer and CRP in ACS （1.48 mg/L± 0.45 mg/L, 21.4 mg/L, respectively） were significantly higher than that in SAP （0.31 mg/L±0.13 mg/L, 5.2 mg/L, respectively） and the control group （0.26 mg/L ± 0.12 mg/L, 4.9 m/L, respectively）, There was a significantly positive correlation between the plasma levels of D- dimer and CRP in ACS. Conclusion Compared with SAP and control group, both plasma levels of D - dimer and CRP elevated obviously in ACS. Both plasma levels of D- dimer and CRP might be regarded as biochemical markers for early ACS.

关 键 词：急性冠脉综合征 稳定型心绞痛 不稳定型心绞痛 心肌梗死 D-二聚体 C反应蛋白 

分 类 号：R541.4[医药卫生—心血管疾病]