血清铁和血清铁蛋白与病毒性肝炎患者肝纤维化指标的关系  

Relationship between serum iron,serum ferritin and hepatic fibrosis indicators in patients with viral hepatitis

作　　者：黄聪武[1] 詹海勇[1] 李国平 郑宗茂[1] 吴灵飞[1] 

机构地区：[1]汕头大学医学院第二附属医院消化内科,汕头515041

出　　处：《山西医科大学学报》2007年第3期218-220,共3页Journal of Shanxi Medical University

基　　金：广东省自然科学基金资助项目(2004B110)

摘　　要：目的研究血清铁和血清铁蛋白与病毒性肝炎患者血清肝纤维化指标(透明质酸、层黏蛋白、人Ⅲ型前胶原、Ⅳ型胶原)的关系。方法采用1 s快速肝穿刺法对39例病毒性肝炎患者和30例病毒标志物阴性对照组取肝组织标本,行HE和铁染色后镜检;同时分别应用原子吸收光谱法、放射免疫法和酶联免疫法检测患者的血清铁、血清铁蛋白、肝纤维化指标。结果对照组和病毒性肝炎患者比较,血清铁、血清铁蛋白测定值差异显著(P<0.05);病毒性肝炎患者肝纤维化指标测定值与对照组间有显著性差异(P<0.05)。血清铁及血清铁蛋白与Ⅳ型胶原具有统计学上的相关性(血清铁r=0.614,P=0.026;血清铁蛋白r=0.549,P=0.019)。病毒性肝炎患者多合并有肝铁过载,肝功能损害程度严重的患者肝组织有明显铁颗粒沉积。结论血清铁、血清铁蛋白测定值可以作为病毒性肝炎患者铁过载的重要指标。Objective To study the relationship between serum iron, serum ferritin and indicators of hepatic fibrosis of patients with viral hepatitis. Methods The liver specimens of 39 patients with viral hepatitis and 30 subjects of negative viral marker were obtained by 1 s liver biopsy. The specimens were stained by haematoxylin-eosin（HE） and Perl＇ s Prussian. The serum levels of iron, ferritin, hyaluronic acid（HA） ,laminin（LN）, human procollagen type Ⅲ（HPC- Ⅲ ）, collagen type Ⅳ （ Ⅳ - C） were examined by atomic absorption spectrum, radioimmunoassay and enzyme-linked immunosorbent assay （ELISA）, respectively. Results Compared with healthy people, serum levels of iron and ferritin in patients with viral hepatitis were significantly different （P〈0.05）. The level of the indicators of hepatic fibrosis in patients with viral hepatitis had statistic value compared with the normal group. There were correlations between serum iron, serum ferritin and serum collagen type Ⅳ （serum iron： r = 0. 614, P = 0. 026 ; serum ferritin： r = 0. 549, P = 0. 019）. Most of the patients with viral hepatitis had iron overload. Compared with the healthy people, iron of liver obviously increased in patients with viral hepatitis. There were a positive relationship between liver functional lesion and iron deposition in liver tissue, Conclusion The serum levels of iron and ferritin may be the important markers of liver iron overload.

关 键 词：铁超负荷 肝炎 病毒性 人 肝硬化 铁 铁蛋白 

分 类 号：R512.6[医药卫生—内科学]