支气管哮喘患者血浆可溶性白介素-2受体水平与气道炎症关系的研究  

Relationship between soluble interleukin-2 receptor and inflammation in bronchus of patients with asthma

作　　者：尹小文[1] 江兴堂[1] 

机构地区：[1]厦门大学附属中山医院呼吸内科,361004

出　　处：《国际呼吸杂志》2007年第6期412-413,共2页International Journal of Respiration

摘　　要：目的 探讨支气管哮喘患者血浆中可溶性的白介素2受体（soluble interleukin-2 receptor,sIL-2R）和气道黏膜的炎症程度的关系。方法 采用ELISA法检测15例哮喘患者和15例健康对照者血浆中sIL-2R，并对支气管黏膜活检标本的炎症细胞定量计数。结果哮喘患者血浆中sIL-2R水平明显高于正常对照组（47．47±13．29）U／mlvs（31．59士4．00）U／ml，（P〈0．05）。哮喘患者的血浆sIL-2R水平与支气管上皮层内嗜酸粒细胞数呈正相关（n=0．82，Pd0．05），与炎症细胞总数呈正相关（n=0．75，Pd0．05）。结论 sIL-2R与哮喘气道炎症相一致，可用于监测气道炎症的活动性。Objective To investigate the relationship between soluble interleukin-2 receptor（sIL-2R） and inflammatory degree in the patients with asthma. Methods Fifteen asthmatic patients and 15 normal subjects were recruited and the concentration of sIL-2R was measured by ELISA, the inflammatory cells in the mucous of bronchus were recorded. Results The serum level of sIL-2R in asthmatic patients was significantly higher than normal subjects （47.47±13.29） U/ml vs V （31.59±4.00） U/ml, （ P〈0.05）. The concentration of sIL-2R showed a significantly positive correlation with the counts of eosinophils and total inflammatory cells in the epithelium （ r s = 0.82, P 〈 0.05; rs = 0.75, P 〈 0.05）. Conclusions The concentration of sIL-2R is correlated with inflammatory cells in the mucous of bronchus and can be used as a noninvasive index of the activity in bronchial inflammation.

关 键 词：支气管哮喘 可溶性白介素2受体 气道炎症 

分 类 号：R5[医药卫生—内科学]