邻卤苯乙酸合成方法的改进  

Improved synthesis of o-halophenylacetic acid

作　　者：蔡可迎[1] 丁明洁[2] 宗志敏[2] 魏贤勇[2] 

机构地区：[1]徐州教育学院化学系,江苏徐州221006 [2]中国矿业大学化工学院,江苏徐州221008

出　　处：《湖北大学学报（自然科学版）》2007年第1期82-84,88,共4页Journal of Hubei University：Natural Science

基　　金：江苏省高新技术产业发展项目(JHB05-33)

摘　　要：以NaOH溶液快速沉淀CuCl2和AlCl2的混合溶液制备了催化剂CuO-Al2O3．在20％NaOH水溶液中，以CuO-Al2O3催化水合肼还原邻硝基苯乙酸得到邻氨基苯乙酸，经重氮化和卤置换反应得到邻卤苯乙酸，收率65％～73％．总收率为40～45％．o-Nitrophenylacetic acids were synthesized in ca. 62% by C2H5ONa-catalyzed condensation of o-nitrotoluene with diethyl oxalate and subsequently by hydrolysis, oxidation with H2O2 and acidation with HCl. They were further converted to o-halophenylacetic acids by CuO-Al2O3-catalyzed reduction with hydrazine hydrate in 20% NaOH aqueous solution, diazonation and substitution with haloatoms in 65%～73% yields. The overall yield is about 40%～45%.

关 键 词：邻卤苯乙酸 邻硝基苯乙酸 邻硝基甲苯 合成 

分 类 号：TQ245.3[化学工程—有机化工]