职业接触二噁英对男工血浆中维生素A稳态的影响  

Effects of occupational exposure to dioxins on vitamin A level in plasma of male workers

作　　者：姜凡晓[1] 董丽[1] 汤乃军[1] 张春梅[1] 赵力军[1] 刘静[1] 任大林[1] 

机构地区：[1]天津医科大学公共卫生学院劳动卫生教研室,天津300070

出　　处：《武警医学院学报》2007年第1期30-33,共4页Acta Academiae Medicinae CPAPF

摘　　要：【目的】从维生素A稳态角度探讨职业接触二噁英可能对男性造成的健康影响,为二噁英的皮肤毒性作用及作用机制提供依据和线索。【方法】采用微量荧光法和ELISA方法分别测定人群血浆中维生素A的含量和视黄醇结合蛋白的浓度。【结果】与对照组相比,暴露组血浆中维生素A含量有所升高但没有统计学意义(P>0.05),而视黄醇结合蛋白的水平出现明显的上升且具有统计学意义(P<0.01)。【结论】职业性接触二噁英对男工血浆中维生素A及视黄醇正常水平具有一定的干扰作用。[Objective] To investigate the effects of occupational exposure to dioxins on vitamin A level in plasma of male workers as the evidences and clues for the pathogenesis of dermal toxicity caused by dioxins. [Methods] The levels of vitamin A and retinoid binding proteins were detected by the trace fluorescence assay and ELISA respectively. [ Results] The levels of vitamin A in the plasma in the exposed group were showed to alter but without significance （ P 〉 0.05）, while the retinol-binding protein had been exhibited to increase with marked significance （ P 〈 0.01）. [ Conclusion] Occupational exposure to dioxins can disturb the normal status of vitamin A and retinoid binding proteins in the plasma of male workers.

关 键 词：二[口恶]英 维生素A 视黄醇结合蛋白 

分 类 号：R135.1[医药卫生—劳动卫生]