注射用加替沙星与西咪替丁注射液配伍稳定性考察  

Stability Study on Gatifloxacin for Injection in Combination with Cimetidine Injection

作　　者：杨继章[1] 刘瑞琴[1] 杨树民[1] 李芳丽[2] 

机构地区：[1]河北医科大学第一医院药剂科,石家庄市050031 [2]河北医科大学药学院,石家庄市050017

出　　处：《中国药房》2007年第11期846-848,共3页China Pharmacy

基　　金：河北省2004年医学科学研究重点课题(04177)

摘　　要：目的:考察注射用加替沙星与西咪替丁注射液在0.9%氯化钠注射液和5%葡萄糖注射液中配伍的稳定性。方法:在(20±1)℃条件下,分别观察及测定8h内配伍液的外观、pH值变化,并用紫外分光光度法测定加替沙星与西咪替丁的含量。结果:2药配伍后2h内外观、pH值和含量无明显变化,但4h时西咪替丁在2种配伍液中的含量均有升高,在0.9%氯化钠注射液中pH值略微上升。结论:注射用加替沙星与西咪替丁注射液可在0.9%氯化钠注射液和5%葡萄糖注射液中配伍使用,但宜在2h内滴注完毕。OBJECTIVE： To study the compatible stability of gatifloxacin for injection and cimetidine injection in 0.9% sodium chloride injection or in 5% glucose injection.METHODS： Changes in appearance and pH value of gatifloxacin in combination with cimetidine within 8 hours after mixing were respectively observed and determined under room temperature（20± 1）℃, and the content was determined by UV spectrophotometry. RESULTS：No significant change was seen in appearance and pH value after two hours of mixing of the two agents.But after four hours of mixing,the content of cimetidine went up in both solvents, and its pH value rose slightly in 0.9% sodium chloride injection.CONCLUSION： Gatifloxacin for injection can be mixed with cimetidine injection in 0.9% sodium chloride injection or 5%glucose for injection to use, but the compatible liquid should be used up in 2 hours.

关 键 词：注射用加替沙星 西咪替丁注射液 配伍 稳定性 紫外分光光度法 

分 类 号：R927.11[医药卫生—药学]