贝那普利对充血性心力衰竭患者血浆脑钠素水平的影响  

Effect of benazepril on plasma brain natriuretic peptide in patients with congestive heart failure

作　　者：王联发[1] 陈绍良[2] 汪海静[1] 吴振西[1] 黄振平[1] 

机构地区：[1]解放军第105医院心内科,合肥230031 [2]南京医科大学附属南京第一医院心脏中心,210006

出　　处：《疑难病杂志》2007年第4期205-207,共3页Chinese Journal of Difficult and Complicated Cases

摘　　要：目的探讨充血性心力衰竭(CHF)患者血浆脑钠素(BNP)水平的变化及贝那普利的干预作用。方法108例CHF患者给予贝那普利2.5mg/d,1周后增加至5～20mg/d,疗程4周,检测用药前后血浆BNP含量的变化。同时选择20例健康体检者为对照组。结果CHF患者血浆BNP水平(462±318)pg/ml较对照组(22±8)pg/ml明显增高(P<0.01),CHF组BNP水平升高与心力衰竭程度呈正相关(r=0.762,P<0.01)。贝那普利治疗后血浆BNP水平明显降低,与治疗前比较差异有非常显著意义(P<0.01)。不同心功能患者血浆BNP水平差异亦有显著意义,依次为IV级>III级>II级(P<0.01)。而不同病因CHF患者血浆BNP水平之间差异无显著意义(P>0.05)。结论心力衰竭时血浆BNP水平明显增高,而贝那普利具有改善心脏功能的作用。Objective To investigate the effect of benazepril on plasma brain natriuretic peptide（BNP） in patients with congestive heart failure （CHF）. Methods The contents of plasma BNP were detected before and after 4-week treatment （2.5 mg/d for a week,then 5 - 20 mg/d for 3 weeks） in 108 patients with CHF （treatment group）. 20 healthy subjects were enrolled as control group. Results The contents of plasma BNP （462 pg/ml ± 318 pg/ml） in treatment group were significantly higher than those （22 pg/ml ± 8 pg/ml） in control group （ P 〈 0.01）. The increase of BNP levels in treatment group was correlated positively with the degree of CHF （ r = 0.762, P 〈 0.01） .The levels of BNP were significantly decreased after treatment, compared with those before treatment （ P 〈 0.01）. There was a significant difference in patients with different degree of cardiac function in the levels of BNP, with the sequence being Ⅳ 〉 Ⅲ 〉 Ⅱ （ P 〈 0.01）. However there was no significant difference in the levels of BNP among patients with CHF caused by different factors （ P 〉 0.05）. Conclusion The plasma BNP levels increase obviously in patients with CHF, and benazepril has a beneficial effect in improving cardiac function.

关 键 词：贝那普利 心力衰竭 充血性 脑钠素 

分 类 号：R541.61[医药卫生—心血管疾病]