Research on the New One Rod Contraceptive Implant Containing Gestodene  

作　　者：Hai-lin CHEN Jian-xing CHEN 

机构地区：[1]Shanghai Institute of Planned Pare, thood Research, Shanghai 200032, China

出　　处：《Journal of Reproduction and Contraception》2007年第2期86-88,共3页生殖与避孕（英文版）

摘　　要：Objective To develop a new contraceptive implant containing gestodene featuring with only one rod for 5 years long effectiveness and safety. Methods Gestodene synthesis, polymer tube designatiou, in vitro or in vivo test, the pilot test was used for the establishing of minimum clinic dosage. Results It had a burst effect at beginning and become constantly releasing since 12th day. It had zero-order releasing, in vitro, the average releasing rate was 17.0-19.1μg/d, the safe dosage was 70.2mg/kg, C1hr. was 2.91 ± 1.25 ng/ml, Tmax was 8.86± 4.32 h, C was 7.31 ± 1.09 ng/ml, Tss was 14 d, Css was 4.16 ±0.48 ng/ml. Twenty-four hours later after removal of the implant, gestodene was ahnost cleaned out in the blood circulation and only trace amount of drug was detected after the removal. Conclusion One rod gestodene implant is a new tong effective contraceptive and may be promising.Objective To develop a new contraceptive implant containing gestodene featuring with only one rod for 5 years long effectiveness and safety. Methods Gestodene synthesis, polymer tube designatiou, in vitro or in vivo test, the pilot test was used for the establishing of minimum clinic dosage. Results It had a burst effect at beginning and become constantly releasing since 12th day. It had zero-order releasing, in vitro, the average releasing rate was 17.0-19.1μg/d, the safe dosage was 70.2mg/kg, C1hr. was 2.91 ± 1.25 ng/ml, Tmax was 8.86± 4.32 h, C was 7.31 ± 1.09 ng/ml, Tss was 14 d, Css was 4.16 ±0.48 ng/ml. Twenty-four hours later after removal of the implant, gestodene was ahnost cleaned out in the blood circulation and only trace amount of drug was detected after the removal. Conclusion One rod gestodene implant is a new tong effective contraceptive and may be promising.

关 键 词：GESTODENE IMPLANT CONTRACEPTIVE 

分 类 号：R169.41[医药卫生—公共卫生与预防医学]