盐酸格拉司琼对兔血管迷走性晕厥的干预作用  

Intervention Effects of Granisetron Hydrochloride on Vasovagal Syncope in Rabbits

作　　者：董燕[1] 王宏伟[1] 黄萍[1] 程佩萱[1] 夏治[1] 张亮品[2] 

机构地区：[1]华中科技大学同济医学院附属同济医院儿科,武汉430030 [2]华中科技大学同济医学院生理学系,武汉430030

出　　处：《实用儿科临床杂志》2007年第5期367-369,共3页Journal of Applied Clinical Pediatrics

基　　金：国家"十一五"攻关课题项目资助(2004BA720A120)

摘　　要：目的研究盐酸格拉司琼对兔血管迷走性晕厥(VVS)的干预作用。方法将24只健康新西兰大白兔随机分为血管迷走性晕厥组(晕厥组)和格拉司琼干预组(格拉司琼组),每组12只。晕厥组采用9g/L盐水静脉注射;格拉司琼组采用格拉司琼注射液静脉注射干预。建立兔血管迷走性晕厥模型,每只均在放血过程中取4个时间点为T1、T2、T3、T4,比较组间各时间点放血时间、血5-羟色胺(5-HT)质量浓度和总放血量,并监测整个实验过程中心率、血压变化。结果1.格拉司琼能延长兔子放血过程中血压反射性升高和失代偿降低时间,使总放血时间也延长(组间T2、T3、T4比较Pa<0.01)。2.组间T2的平均血压和心率均无明显差异。3.在放血过程中5-HT质量浓度有上升趋势,在血压明显下降时明显升高(晕厥组T3vsT1P<0.0001,T4vsT3P<0.001);格拉司琼对血压升高最快时相和降低最快时相5-HT的生成无明显影响。4.格拉司琼组较晕厥组至T4时的总放血量明显增加[76.10±15.36)mLvs(55·30±13.52)mL,P<0.05]。5.实验结束时晕厥组10只兔子抽搐,最终血压、心率消失死亡(83%)。格拉斯琼组有11只兔子无明显抽搐,因呼吸停止死亡(92%)。结论盐酸格拉司琼能显著减弱或避免Bezold-Jarisch反射的出现,增强兔子对失血模型中脑缺血和急性机体供血不足的耐受性,从而达到预防和治疗VVS的目的。Objective To study the effects of granisetron hydrochloride on vasovagal syncope （VVS） in rabbits. Methods Twenty -four healthy New Zealand rabbits were divided stochastically into control group and intervention group, 12 in each group. The control group was injected intravenously with normal saline. The intervention group was injected intravenously with granisetron hydrchloiride. Rabbit VVS models were established, each was taken at 4 points in time in the bloodletting process ： T1, T2 ,T3, T4, to compare the bloodletting time, the concentration of 5 - hydroxytryptamine（5 -HT） in T2,T3,T4 and the total blood volume between the groups, and monitor the heart rate, blood pressure during the entire process. Results 1. The time of intervention group in T2, T3, T4 was longer than the time of control group obviously （ P 〈 0.01 ）. 2. The mean blood pressure and the heart rate in T2 between the 2 groups had no significant difference. 3. In control group, the concentration of 5 - HT in T3 had significant difference compared with that in T1 （ P 〈 0. 0001 ）. So did T4 compared with that in T3 （ P 〈 0.001 ）, while the concentration compared that in T1, T2, T3 between the 2 groups had no significant difference. It had the significant difference in T4 （ P 〈 0.01 ）. 4. The total blood volume of the intervention group in T4 was more than the volume of control group obviously [ （ 76.10 ± 15.36） mL vs （ 55.30 ± 13.52） mL, t = 2.781 P 〈 0.05 ]. 5. Finally in control group, there were 10 rabbits twitched to death, whose blood pressure and the heart rate vanished in the end （83%）. While in intervention group, 11 rabbits died without twitching, but died of no breath （92%）. Conclusions Granisetron hydro- chloride can weaken or prevent Bezold - Jarisch reflex and can improve the endurance of cerebral ischemia and blood - supply deficiency. Granisetron hydrochloride can be the medicine to prevent or cure VVS.

关 键 词：盐酸格拉司琼 晕厥 血管迷走神经性 干预性研究 

分 类 号：R725.4[医药卫生—儿科]