促红细胞生成素治疗早产儿脑损伤的效果  

Effect of Erythropoietin Therapy on Brain Damage in Preterm Infants

作　　者：宋燕燕[1] 孙新[1] 赵小朋[1] 叶青青[1] 李坚[1] 黄志坚[1] 肖华[1] 李智华[1] 杨默[2] 

机构地区：[1]广州医学院附属广州市妇婴医院儿科,广州510180 [2]香港大学儿科学系

出　　处：《实用儿科临床杂志》2007年第6期456-457,共2页Journal of Applied Clinical Pediatrics

基　　金：广东省自然科学基金课题资助(5013928)

摘　　要：目的探讨促红细胞生成素（EPO）在防治早产儿脑损伤中的作用。方法早产儿30例。男23例，女7例；随机分为常规治疗组、EPO治疗组，各15例。EPO治疗组于生后即开始予EPO治疗。所有患儿随诊至1岁，定期行脑电图、脑干诱发电位（ABR）检查及头颅B超等影像学检查，并于纠正胎龄40周行新生儿行为神经检测（NBNA）。结果1．EPO治疗组NBNA评分正常者占73．33％，明显高于常规治疗组（26．67％），差异有显著性（P〈0．05）；2．纠正胎龄1个月时二组患儿ABR异常率比较差异无统计学意义（P〉0．05），随访至3～6个月时，EPO治疗组ABR异常率明显小于常规治疗组（P〈0．05）。EPO治疗组后期ABR的异常程度较前明显减轻。结论早期使用EPO可改善早产儿预后，减少或减轻早产儿脑损伤。Objective To explore the effect of erythropoietin （EPO） therapy on brain damage in infants. Methods Thirty preterm infants （23 males and 7 females born in our hospital from Sep. 2005 to Mar. 2006） were divided into two groups randomly. The routine treatment group and the EPO treatment group both consisted of 15 infants. EPO was administered to EPO treatment group promptly after birth. All infants were followed up until 1 year after birth. Brain ultrasound scan, auditory brainstem response （ABR） and eletroencephalogram （EEG） were performed. Neonatal behavioral neurological assessment（NBNA） was assigned at 40 weeks of corrected gestational age. Results 1. EPO treatment group counted for a normal NBNA rate of 73.33%, apparently higher than that of routine treatment group （26.67%） ,and there was signilleant difference （P 〈0.05）. 2. Comparison of functional test results： the two groups showed no difference in abnormal ABR rate （P 〉 0.05 ）. When followed up to 3 - 6 months after birth, study group＇s abnormal ABR rate dropped from 42.86% to 21.43 % while that of routine treatment group dropped from 73.33% to 69.23% ,EPO treatment group＇s abnormal ABR rate was apparently lower than that of routine treatment group （ P 〈 0.05 ）. Besides, abnormal ABR level decreased during later period of following up. Conclusion EPO can improve preterm infants＇ prognosis and reduce incidence of sequelae.

关 键 词：婴儿 早产 脑损伤 促红细胞生成素类 

分 类 号：R722.6[医药卫生—儿科]