高危型人乳头瘤病毒检测在宫颈病变筛查中的意义  

The role of HR-HPV test in the sreening of cervical lesion

作　　者：赵超[1] 崔淑慧[1] 赵昀[1] 屠铮[1] 王建六[1] 魏丽惠[1] 

机构地区：[1]北京大学人民医院妇产科,100044

出　　处：《北京医学》2007年第4期214-216,共3页Beijing Medical Journal

摘　　要：目的探讨高危型人乳头瘤病毒(HPV)检测在宫颈病变筛查中的临床意义。方法对2003年10月至2005年1月在我院就诊的1476例患者进行超薄液基细胞学检查、高危型HPV检测及阴道镜检查。结果1476例患者中HPV感染阳性例数为654例,占44.31%,平均年龄为36.57岁;阴性例数为822例,占55.69%,平均年龄为36.48岁。高危型HPV感染阳性率随宫颈病变程度加重而明显升高。HPV高危型阳性患者中,病理诊断宫颈炎占35.7%(444/1244);宫颈上皮内瘤变(CIN)I级占84.3%(70/83);CINII级占90.0%(54/60);CINIII级占95.8%(69/72);早期浸润癌为100%(17/17)。结论在宫颈病变的早期筛查中,联合进行细胞学、高危型HPV-(第2代杂交捕获实验)HC2检测、阴道镜及病理学检查有重要意义。bjective This study was performed to investigate the role of the HR-HPV test in the screening for the patients with cervical lesion. Methods From october 2003 to January 2005, patients in the gynecological department of Peking University People＇s Hospital were enrolled in this study. To compare the different methods used for screening of cervical lesion, the Liquid-based Cytology, HR-HPV test and colposcopy/pathology analysis were performed parallelly in 1476 cases. The average age of this study population was 35.6 years. Results In the 1476 cases, compared with the final pathological diagnosis, the ratio of HR-HPV infection was increased with aggravation of cervical lesion：35.7% （444/1244） in cervicitis ; 84.3%（70/83） in CIN-Ⅰ; 90.0% （54/60） in CIN-Ⅱ; 95.8% （69/72） in CIN Ⅲ and 100% （17/17） in early invasive cancer. Conclusions Combined with cytology, HR-HPV test and colposcopy provide very helpful information for the screening of cervical lesion.

关 键 词：人乳头状瘤病毒 宫颈癌 

分 类 号：R711.74[医药卫生—妇产科学]