内蒙古地区蒙古族儿童过敏性紫癜与HLA-DRB1等位基因相关性的研究  

STUDY OF CORRELATION BETWEEN HLA-DRB1 ALLELES AND ANAPHYLACTOID PURPURA OF MONGOL JUVENILE PATIENTS IN INNER MONGOLIA

作　　者：于慧玲[1] 任少敏[2] 夏养志[1] 

机构地区：[1]内蒙古医学院病理教研室,内蒙古呼和浩特010059 [2]内蒙古医学院附属医院儿科

出　　处：《内蒙古医学院学报》2007年第1期16-19,共4页Acta Academiae Medicinae Neimongol

基　　金：内蒙古自治区自然科学基金项目(99030201)

摘　　要：目的:探讨蒙古族儿童过敏性紫癜(AP)的遗传背景及免疫学发病机制,为明确AP的病因学及预后提供免疫学方面的资料。方法:采用分析性研究策略和聚合酶链反应-序列特异性引物分型技术(PCR-SSP)对57例内蒙古地区蒙古族儿童过敏性紫癜病人和102例正常蒙古族儿童进行HLA-DRB1等位基因型别分析。结果:HLA-DRB1*110x的基因频率在AP组较正常对照组明显升高(P<0.05);HLA-DRB1*120x的基因频率在AP组较正常对照组明显降低(P<0.05)。其它HLA-DRB1等位基因频率在两组间的分布则无明显差异(P>0.05)。结论:HLA-DRB1*110x与AP的易感性呈正相关,可能是AP的易感基因。HLA-DRB1*120x与AP的易感性呈负相关,可能是AP的保护基因。Objective：To investigate the correlation between polymorphism of HLA- DRB1 alleles and anaphylactoid purpura （AP） of Mongol juvenile patients in order to interpret the genetic basis of susceptibility and immune pathogenesis of AP. Methods：57 Mongol juvenile patients with AP and 102 normal Mongol children controls in Inner Mongolia were tested for the analysis of HLA - DRB1 allelic types by means of PCR - SSP technique. Results： HLA - DRB1 ＊ llOx gene frequency was significantly higher in patients with AP than that in the controls（P 〈0. 05） ;HLA -DRB1 ＊ 120x gene frequency was significantly lower in patients with AP than that in the controls （P 〈 0. 05 ）. There was no statistical significance in other alleles between the two groups（P 〉0. 05 ）. Conclusion： HLA- DRB1 ＊ 1 10x is positive correlated with susceptibility of AP which is probably the susceptible gene of Mongol juvenile patients with AP in Inner Mongolia, and HLA - DRB1 ＊ 120x is negative correlated with that of AP, which is probably the protective gene of AP.

关 键 词：人类白细胞抗原 过敏性紫癜 蒙古族 聚合酶链反应-序列特异性引物 

分 类 号：R392.2[医药卫生—免疫学] R725.54[医药卫生—基础医学]