石菖蒲挥发油β-细辛醚对支气管哮喘的影响  

Influence of β-asaricin in Volatile Oil from Rhizoma Acori Tatarinowii on Bronchial Asthma

作　　者：徐建民[1] 

机构地区：[1]湖北中医学院生化教研室,武汉430061

出　　处：《广州中医药大学学报》2007年第2期152-154,共3页Journal of Guangzhou University of Traditional Chinese Medicine

摘　　要：【目的】观察石菖蒲挥发油β-细辛醚喷雾给药对支气管哮喘模型豚鼠的影响。【方法】豚鼠30只,随机分为模型组、氨茶碱组和β-细辛醚组,各组豚鼠喷雾给药7 d后,以组织胺(His)和乙酰胆碱(Ach)喷雾复制哮喘模型,观察药物对模型豚鼠引喘潜伏期和跌倒潜伏期的影响;取豚鼠气管,置克—亨氏液浴槽内,观察药物对His和Ach造模后,离体气管平滑肌张力的影响;豚鼠30只,分组同前,先以40 g/L卵蛋白(OVA)和Al(OH)3致敏,连续喷雾给药7 d后,再以OVA喷雾引喘,观察各药物对模型豚鼠支气管和肺组织中肥大细胞脱颗粒数的影响。【结果】β-细辛醚可延长His和Ach引喘的模型豚鼠的哮喘发作潜伏期和跌倒潜伏期;拮抗因His和Ach所致的离体支气管平滑肌痉挛;抑制由OVA和Al(OH)3引喘的模型豚鼠的肥大细胞脱颗粒,与模型组比较均有显著性差异(P<0.05或P<0.01或P<0.001),与氨茶碱的作用相仿。【结论】β-细辛醚具有一定的平喘和抗过敏作用。[ Objective] To observe the effect of β-asaricin spray on guinea pigs bronchial asthma. [ Methods] Thirty FMMU guinea pigs were equally randomized into three groups： A （treated with β-asaricin spray）, B （treated with aminophylline） and C （model）. Ater 7-day treatment, the guinea pigs received nebulization of histamine and acetylcholine to induce asthma models. And the effect of β-asaricin on asthmatic attack latency and fall latency in guinea pigs was observed. The isolated trachea was used to observe the effect of β-asaricin on tension of isolated bronchial smooth muscle. Other 30 guinea pigs were also randomized into three groups. The guinea pigs were sensitized with 40 g/ L ovalbumin and Al （OH）3 firstly, treated with nebulization therapy for 7 days, and then induced asthma by nebulization of ovalbumin to observe the effect on the degranulatiou of mastocytes in bronchus and lung tissue. [Results] β-asaricin prolonged asthma latency and fall latency, inhibited the degranulation of mastocytes induced by ovalbumin and Al （OH）3, and promoted the relaxation of bronchial smooth muscle induced by histamine and acetylcholine, the difference being significant （P 〈 0.05 or P 〈 0.01 or P 〈 0.001 compared with the model group）. [Conclusion] β- asaricin has certain antiasthma and antiallergic actions.

关 键 词：β-细辛醚/药理学 支气管哮喘/中药疗法 疾病模型 动物 豚鼠 

分 类 号：R285.5[医药卫生—中药学]