2,6-二甲基苯硼酸的制备  

Preparation of 2,6-dimethylphenyl boronic acid

作　　者：张永强[1] 邓燕[1] 蒋欢妹[1] 侯清麟[1] 贺全国[1] 

机构地区：[1]湖南工业大学绿色包装与生物纳米技术应用重点实验室,湖南株洲412008

出　　处：《化学试剂》2007年第4期241-242,共2页Chemical Reagents

摘　　要：以硼酸三丁酯为硼化剂,利用格氏试剂法制备2,6-二甲基苯硼酸,考察了温度和反应物配比对产率的影响。先制得格氏试剂(产率98.2%),然后在-10℃与硼酸三丁酯进行亲核取代,快速升温至20℃,经酸性水解得产品,总产率72.2%。对产品进行了核磁共振谱和质谱表征。2,6-Dimethylphenyl boronic acid was prepared using tributyl borate and the Grignard reagent. An optimized process was obtained by investigating the influence of the temperature and reactants ratio on the product yield. First, the Grignard reagent was prepared （with the yield equating to 98.2 % ）, and then reacted with tributyl borate at - 10 ℃ ,followed by hydrolysis in an acidic medium after the temperature was increased to 20 ℃ in a short time. The isolated product yield was 72.2 %. The product was characterized by ^1HNMR and mass spectrometry.

关 键 词：格氏试剂 2 6-二甲基苯硼酸 制备 

分 类 号：O627.3[理学—有机化学]