以金纳米粒子为探针比色法检测顺铂  

Colorimetric Detection of cis-Pt with Gold Nanoparticle Probes

作　　者：孙琳琳[1] 刘殿骏[1] 王振新[1] 

机构地区：[1]中国科学院长春应用化学研究所电分析化学国家重点实验室,长春130022

出　　处：《高等学校化学学报》2007年第4期652-654,共3页Chemical Journal of Chinese Universities

基　　金：国家自然科学基金(批准号:20675080)资助.

摘　　要：A novel method of colorimetric assay for determining cis-Pt (cis-diammino-dichloroplatinum Ⅱ) was found by the binding affinities between cis-Pt and DNA based on the change of surface plasmon resonance band of gold nanoparticles. The red-shift of the maximum band of the surface plasmon resonance band of gold nanoparticles increased linearly with the logarithm of the cis-Pt concentration from 40 to 2000 nmol/L and the detection limit is 40 nmol/L when the concentration of gold nanoparticles is 4 nmol/L. The colorimetric readout can be visualised with the naked eyes.A novel method of colorimetric assay for determining cis-Pt （cis-diammino-dichloroplatinum Ⅱ ） was found by the binding affinities between cis-Pt and DNA based on the change of surface plasmon resonance band of gold nanoparticles. The red-shift of the maximum band of the surface plasmon resonance band of gold nanoparticles increased linearly with the logarithm of the cis-Pt concentration from 40 to 2000 nmol/L and the detection limit is 40 nmol/L when the concentration of gold nanoparticles is 4 nmol/L. The colorimetric readout can be visualised with the naked eyes.

关 键 词：顺铂 金纳米粒子 比色法 

分 类 号：O657[理学—分析化学]