细胞因子与过敏性哮喘  

Cytokines and allergic asthma

作　　者：徐艳华[1] 郭胤仕[1] 

机构地区：[1]上海交通大学医学院附属仁济医院呼吸科,200127

出　　处：《国际呼吸杂志》2007年第7期499-501,共3页International Journal of Respiration

摘　　要：支气管哮喘是一种慢性气道炎症性疾病。在气道炎症反应中，无论是Th2型细胞因子（IL-4、IL-5、IL-13等），还是Th1型细胞因子IFN-γ均起着重要作用。新近研究进一步表明调节性T细胞（Treg）产生的细胞因子也与过敏性哮喘的发病密切相关。Allergic bronchial asthma is characterized by chronic airway inflammation. It was proposed that the imbalance of Th1/Th2 was responsible for the pathogenesis of asthma. In recent years,accumulating data have identified Th2 cytokines （IL-4,IL-5 and IL-13） as major contributors to asthma. Interestingly,the Th1 cytokine IFN-γ has recently been shown to act concurrently with Th2 cytokines in maintaining the chronic airway inflammatory response. Most recently, evidence suggests that suppression of Treg cells may contribute to the underlying immune mechanisms involved in allergic asthma.

关 键 词：细胞因子 哮喘 TH1 TH2 调节性T细胞 

分 类 号：R5[医药卫生—内科学]