Th1／Th2炎症极化与肺气肿和肺纤维化  

Th1/Th2 polarization in emphysema and pulmonary fibrosis

作　　者：施维[1] 张劲农[1] 

机构地区：[1]华中科技大学附属协和医院呼吸病研究室,武汉430022

出　　处：《国际呼吸杂志》2007年第7期551-553,共3页International Journal of Respiration

摘　　要：肺气肿具有Ⅰ型T辅助细胞（Th1）炎症极化的特征，表现为损伤过度和修复不足，肺实质的破坏增加，肺间质变薄。与之相反，肺纤维则具有Ⅱ型T辅助细胞（Th2）炎症极化，表现为损伤后修复过度，肺间质增厚，胶原沉积。通过调控Th1和Th2的炎症趋势来控制肺组织的损伤和修复的结局可能会为肺气肿和肺纤维化的防治提供新思路。Emphysema has the characteristic of Th1 polarization reflecting excessive damage and insufficient repair in tissue, with the pulmonary parenchyma impaired heavily and pulmonary interstititium thinned. Oppositely, pulmonary fibrosis is characterized by Th2 polarization, reflecting excessive repair following damage,with pulmonary interstititium thickened and collagen deposition. Controlling the result of damage and repair in lung tissue by regulating Th1/Th2 responses may provide novel prevention and treatment to emphysema and pulmonary fibrosis.

关 键 词：Th1/Th2炎症极化 肺气肿 肺纤维化 肺间质 

分 类 号：R563[医药卫生—呼吸系统]